PAROXETINE EFFECTS ON RESPONSE TO MENTAL STRESS IN PATIENTS WITH STABLE ANGINA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本双盲交叉安慰剂对照交叉研究旨在评估帕罗西汀1个月对稳定型心绞痛或有心绞痛病史患者在2项精神应激任务中心血管反应和心理不适的影响。筛选访问后，受试者随机接受一个月的帕罗西汀（10mg/天，1周，随后20mg /天）或安慰剂治疗，之后他们返回GCRC进行“精神压力测试”。研究人员在受试者完成两项可能会导致一些精神压力的任务时，测量了他们的心血管反应。这些任务包括简短的演讲和心算任务。从精神压力测试前半小时开始，一直持续到访问结束，通过自动血压测量装置每隔1至2分钟测量一次血压和心率。在精神压力测试之前（在放松阶段结束时）和每次精神压力任务期间立即抽血（20cc）。在心理压力测试完成后，评估手术过程中的心理不适。在接下来的一个月里，受试者接受交替治疗，之后重复进行“精神压力测试”。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This double-blind crossover placebo controlled crossover study is assessing the effect of 1 month of paroxetine administration on cardiovascular response and psychological discomfort during 2 mental stress tasks in patients with stable angina or a history of angina. After a screening visit, subjects are randomized to receive one month of treatment with either paroxetine (10mg/day for 1 week followed by 20 mg/day) or placebo after which they return to the GCRC for "mental stress testing." Cardiovascular response is measured while subjects perform two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. Starting one-half hour prior to mental stress testing and continuing until the conclusion of the visit, blood pressure and heart rate are measured at 1 to 2 minute intervals via an automated blood pressure measuring device. Blood (20 cc's) is drawn immediately prior to mental stress testing (at the end of the relaxation phase) and during each mental stress task. Psychological discomfort during the procedure is assessed after mental stress testing is complete. For the following month, subjects receive the alternate treatment after which "mental stress testing" is repeated.