STRENGTH TRAINING FOR OBESITY PREVENTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。最近肥胖流行率的增加使预防肥胖成为一个明确而紧迫的公共卫生问题。美国女性平均每年增重0.5公斤，其中60%到80%可以认为是脂肪。年龄在25至44岁之间的超重女性比男性、年龄较大或较瘦的女性更容易出现体重显著增加（体重指数增加5 kg/m2）。腹部总脂肪和内脏脂肪增加与多种肥胖合并症有关，包括胰岛素抵抗、高血压和血脂异常。成功减肥和维持体重的困难导致一些专家小组建议超重和轻度肥胖者避免体重增加，而不是减肥。体力活动随着年龄的增长而减少，而热量摄入保持稳定或略有下降。有强有力的观察证据表明，体育活动可以预防或减少与年龄相关的脂肪增加。这项随机、控制的行为干预试验将检验这样一个假设：与标准治疗组（n=80）相比，80名年龄在25至44岁之间的超重至轻度肥胖绝经前妇女（BMI 25-25 kg/m2），在2年内定期参加每周两次的力量训练计划，可以预防与年龄相关的体脂增加（总脂肪和腹侧脂肪）。这项研究的总体目标是防止身体脂肪增加，减少与肥胖有关的健康风险。治疗效果将根据胰岛素敏感性、血压、血脂、肌肉力量和力量训练依从性的社会心理预测指标进行评估。这种方法的创新之处在于它的简单性和充分参与所需的时间最少（每周2次锻炼）。对这种创新方法的初步研究表明，在12个月内，88%的人参加了运动，并且在试验研究结束时（9个月），治疗对总体脂率的影响保持不变。这支持了所建议的干预方法的可行性和长期有效性的潜力。这项疗效试验成功的长期意义在于，这种适度的行为改变可以预防中年女性中常见的脂肪增加和相关并发症。GCRC的作用：身高和体重测量；静息血压；全身DEXA扫描的身体成分；DEXA扫描骨密度；抽取10大汤匙血液并准备储存；胰岛素改良静脉葡萄糖耐量试验。在基线、第一年和第二年进行测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent obesity prevalence increases have made obesity prevention a clear and pressing public health issue. The average US woman gains about 0.5 kg per year, 60 to 80% of which can be assumed to be fat. Overweight women aged 25 to 44 have a higher prevalence of significant weight gains (BMI increases of 5 kg/m2) than men or older or thinner women. Total and viseral abdominal fat gains are associated with a variety of obesity co-morbidities, including insulin resistance, hypertension, and dyslipidemia. The difficulty in successfully losing weight and maintaining weight loss has resulted in recommendations from several expert panels to advise overweight and mildly obese individuals to avoid weight gains rather than lose weight. Physicial activity is observed to decline with age while caloric intake remains stable or declines slightly. There is strong observational evidence that physical activity could prevent or attenuate age associated fat gains. This randomized, controlled behavioral interventional trial will test the hypothesis that regular participation twice weekly strength training program over 2 years, can prevent age associated body fat increases (total and siceral abdominal fat) in 80 overweight to mildly obese premenopausal women( BMI 25-25 kg/m2) between the ages of 25 and 44 years, compared to a "standard care group" (n=80). The overall aim of the study is to prevent body fat gains and to reduce health risks associated with obesity. Treatment effects will be assessed for insulin sensitivity, blood pressure, blood lipids, muscle strength, and psychosocial predictors of strength training adherence. The innovation of this approach rests in its simplicity and the minimal time requirement for full participation (2 exercise sessions weekly). A preliminary study of this innovative approach resulted in 88% exercise attendance over 12 months and maintenance of treatment effects on total body fat percentage to the end of pilot study measurements (9 months). This supports the feasibility and potential for long term efficacy of the proposed intervention approach. The long-term implication of success in this efficacy trial would be that this modest behavior change could prevent the fat gains and associated co-morbidities commonly observed in midlife women. Role of GCRC: Height and weight measurements; resting blood pressure; body composition by total body DEXA Scan; bone mineral density by DEXA scan; blood draw of 10 tablespoons of blood and prep to store; insulin modified intravenous glucose tolerance test. Measurements to occur at baseline, year 1, and year 2.