GENERAL CLINICAL RESEARCH CENTER

超出提供的空间。 港湾-加州大学洛杉矶分校医学中心的综合临床研究中心(GCRC)现已进入运营的第31个年头。 该提案要求在五年内(12/1/01至22/30/06)继续支持住院单位(1000天)、门诊 设施(5,500人次)、加州大学洛杉矶分校的围产期临床研究中心(PCRC)和卫星PCRC 金-德鲁医疗中心。雪松的GCRC卫星正在增长，研究数量增加了 包括围产期研究以及基因分型(630,833个基因类型)和细胞系的新活动方案 基因分型-表型核心的发展(2,614个细胞系)。当前应用程序包含来自 港湾-加州大学洛杉矶分校和来自锡达斯-西奈医学中心的72项协议。在过去的五年中， 在海港和雪松的GCRC之间的合作，例证是 合作调查人员和共享协议(16个协议)。这种协作活动的大部分内容都包含在 最近资助的基因分型-表型核心的围产期研究以及基因分型和细胞系发展，网址为 锡达斯-西奈。这两个机构的GCRC都是指导临床的临床研究培训的重点 通过MH资助和其他外展计划，将初级教员级别的研究实习生提供给高中生。 我们的研究重点是雄激素治疗和男性避孕药的开发；药物遗传学和 种族心理生物学；霉菌感染机制；运动训练与老年男性和 慢性病；母体胎儿渗透调节；高血压和慢性疾病的遗传基础 炎症性肠病。我们继续支持大量的门诊研究(例如，妇女健康倡议， 糖尿病基因鉴定)、高强度住院研究(例如代谢和多重抽样研究)、围产期 常见疾病(糖尿病、动脉粥样硬化、高血压、骨质疏松症)的研究和遗传学。满足…的需要 我们的研究人员和不断变化的临床研究重点，我们建议：1)进一步扩大我们的门诊研究 能力(港湾新的门诊设施，两个中心的门诊量增加)；2)增加数据和安全性 监测顾问/监测员，以保障研究对象的安全；3)鼓励 通过在雪松建立PCRC建立三个中心；和4)通过以下方式增加对细胞系和基因/表型核心的利用 两个中心都有。

EXCEED THE SPACE PROVIDED. The General Clinical Research Center (GCRC) at Harbor-UCLA Medical Center is now in its 31st year of operation. This proposal requests continued support for five years (12/1/01 to 22/30/06) for an inpatient unit (1000 days), outpatient facilities (5,500 visits), a Perinatal Clinical Research Center (PCRC) at Harbor-UCLA and a satellite PCRC at King-Drew Medical Center. The GCRC satellite at Cedars is growing with a 64% increase in number of research protocols with new activities encompassing perinatal research as well as genotyping (630,833 genotypes) and cell line development (2,614 cell lines) in the Genotyping-Phenotyping Core. The current applicationcontains 100 protocols from Harbor-UCLA and 72 protocols from Cedars-Sinai Medical Center. The past five years have witnessed an increased collaboration between the GCRCs at Harbor and Cedars as exemplified by a twofold increase in the number of collaborating investigators and shared protocols (16 protocols). Much of this collaborative activity is encompassed in perinatal research as well as genotyping and cell line development in the recently funded genotyping-phenotyping core at Cedars-Sinai. The GCRCs at both institutions are the focus of clinical research training from the mentored clinical research trainee at the junior faculty level to high school students through MH funded and other outreach programs. Our research focus has been on androgen therapy and male contraceptive development; pharmacogenetics and psychobiology of ethnicity; mechanisms of infection by mycoses; exercise trainingand frailty in older men and men with chronic diseases; maternal fetal osmoregulation, and the genetic basis of diseases including hypertension and chronic inflammatory bowel disease. We continue to support high volume outpatient studies,( e.g., Women's Health Initiative, identification of diabetic genes), high intensity inpatient studies (e.g., metabolic and multiple sampling studies), perinatal research, and genetics of common diseases (diabetes, atherosclerosis, hypertension, osteoporosis). To meet the needs of our investigators and the changing clinical research focus, we propose: 1) to further expand our outpatient research capability (new outpatient facilities at Harbor, increased outpatients visits at both centers); 2) to add data and safety monitoring advisors/monitors to safeguard the safety of research subjects; 3) to encourage collaboration between the three centers by establishing a PCRC at Cedars; and 4) to increase use of the cell-line and genotype/phenotype core by both centers.