ROLES OF 20-HYDROXYEICOSATETRAENOIC ACIDS (20-HETE) IN EXCECISE PRESSOR REFLEX

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在运动过程中，交感神经系统（SNS）被激活，导致血压、心率和周围血管收缩的增加。SNS激活的两种基本理论已经发展起来：由机械敏感（机械感受器）和化学敏感（化学感受器）传入触发的中枢指令和运动压力反射。在这项研究中，我们将重点关注代谢受体（特别是前列腺素），并观察是否通过用酮咯酸阻断前列腺素的作用，它会减少对握力运动的反射反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During exercise, the sympathetic nervous system (SNS) is activated and contributes to an increase in blood pressure, heart rate and peripheral vasoconstriction. Two basic theories of SNS activation have evolved: central command and the exercise pressor reflex triggered by mechanically sensitive (mechanoreceptors) and chemically sensitive (chemoreceptors) afferents. In this study, we will focus on metaboreceptors (specifically prostaglandins) and see if by blocking the action of prostaglandins with Ketorolac, it will decrease the reflex response to handgrip exercise.