MR OF BRAIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目开发了用于成像和光谱分析的海马体可重复磁共振研究的最佳方法。特别是，对海马体的重复和纵向评估对于癫痫和衰老等神经系统疾病的研究非常重要。因此，这个项目开发了完全倾斜的成像和分析软件，以半自动的方式共同注册和一致地评估海马体的新陈代谢。虽然文献表明，在整个海马区研究中有10-20%的变异系数，但在n=10名对照志愿者(每人研究两次)中，倾斜联合配准方法的示范提供了单个海马体素的标准偏差为9%，整个海马区的标准偏差为3.5%。这项工作已经被接受为国际磁共振学会2004年的平台讨论，并已提交给Magn res Medicine，引用GCRC。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has developed optimal approaches to the reproducible magnetic resonance study of the hippocampus for imaging and spectroscopic studies. In particular, repeated and longitudinal evaluation of the hippocampus is important for studies in epilepsy and aging, amongst other neurological diseases. Thus this project has developed wholly obliqued imaging together with analysis software to co-register and consistently evaluate hippocampal metabolism in a semi-automated fashion. While the literature demonstrates 10-20% CV in whole hippocampal studies, demonstration of the obliqued-co-registered approach in n=10 control volunteers (each studied twice) provide a standard deviation of difference of 9% for individual hippocampal voxels and 3.5% over the entire hippocampus. This work has been accepted as a platform discussion to the Int'l Society for Magnetic Resonance 2004 and has been submitted Magn Res Medicine, citing the GCRC.