OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尽管轻度创伤性脑损伤(MTBI)是儿童最常见的损伤之一，但对儿童mTBI后的康复过程和长期功能后遗症，包括遗传因素的影响，还缺乏系统的研究。将多态等位基因与神经认知结果联系起来是确定某些基因是否有助于mTBI后恢复的一种策略。然而，等位基因多态研究需要明确定义和验证的结果测量方法和与感兴趣的等位基因频率相适应的样本量。本协议描述了国家儿童医学中心、匹兹堡大学医学中心、运动医学震荡计划和达特茅斯·希区柯克医学中心之间的4阶段、4年多中心合作研究的第一阶段，即试点阶段，有两个目标。第一个目标是开发一种适用于6-18岁儿童的心理测量学测试组，该测试组易于管理、便携和可重复，同时在检测和监测儿童和青少年的mTBI的神经认知和行为结果方面也是敏感的。第二个目的是确定选定的候选基因的等位基因频率，这些基因可能与mTBI后的神经认知结果有关。总而言之，这些先导数据将为有效的遗传关联研究提供基础，以确定有助于儿童mTBI后神经认知恢复的遗传因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery of after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 4-year-multi-center collaborative research study between Children's National Medical Center, University of Pittsburgh Medical Center, Sports Medicine Concussion Program, and Dartmouth Hitchcock Medical Center with two aims. The first aim is to develop a psychometrically-sound test battery for children aged 6-18 years that is easily administered, portable, and repeatable while sensitive in detecting and monitoring neurocognitive and behavioral outcomes of mTBI in children and adolescents. The second aim is to determine the allelic frequency of selected candidate genes that may be associated with neurocognitive outcome after mTBI. Together, these pilot data will provide the basis for a valid genetic association study for identifying genetic factors contributing to neurocognitive recovery after mTBI in children.