MRI STUDIES IN DEPRESSION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。尽管众所周知的压力，焦虑和抑郁症的关联，焦虑和紧张的生活事件对抑郁症的神经生物学观察报告的影响还没有得到明确的检查。压力和焦虑可能会引发一系列神经生物学事件，包括激活身体的主要压力防御系统和激活与获得和维持恐惧有关的大脑回路。在这项研究中，磁共振成像（MRI）技术，包括形态测量MRI，磁共振波谱（MRS），和功能MRI将被用来检查辊的压力和焦虑在调制抑郁症的结构，化学和功能措施。基于抑郁症的神经解剖学模型，我们将重点关注两个主要的大脑区域，这两个区域都被认为是易受压力影响的：海马体和前额叶皮层。抑郁受试者将通过共病焦虑和早期和近期创伤/压力史的测量进行全面表征。四个抑郁症患者和四个匹配的健康对照组，招募在山。西奈医疗中心，将接受形态测量MRI，MRS和功能MRI测试。所有抑郁症患者将在SSRI氟西汀治疗后重新进行测试，应答状态和临床指标的变化作为协变量纳入数据分析。作为可靠性指标，将对4例健康对照进行重新检测。该协议的主要优势在于跨模态数据的分析，允许探索神经化学和功能之间的关系，以及焦虑对抑郁症神经生物学研究结果的影响，以综合的方式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the well-known assocation of stress, anxiety and depression, the impact of anxiety and stressful life events on the neurobiological observations reported in depression have not been clearly examined. Stress and anxiety may set in motion a series of neurobiological events including activation of the body's major stress-defense systems and activation of brain circuitry involved in the acquisition and maintenance of fear. In this study, magnetic resonance imaging (MRI) techniques, including morphometric MRI, magnetic resonance spectroscopy (MRS), and functional MRI will be used to examine the roll of stress and anxiety in modulating structural, chemical and functional measures of depression. Based on neuroanatomical models of depression, we will focus on two main brain areas, both known to be vulnerable to stress: the hippocampus and the prefrontal cortex. Depressed subjects will be thoroughly characterized on measures of comorbid anxiety and history of early and recent trauma/stress. Four depressed subjects and four matched healthy controls, recruited at Mt. Sinai Medical Center, will undergo morphometric MRI, MRS, and functional MRI testing. All depressed patients will be re-tested post-treatment with the SSRI fluoxetine, with response status and change in clinical measures included as covariates in the data analyses. The four healthy controls will be re-tested as a measure of reliability. A major strength of this protocol lies in the analysis of cross-modal data, allowing the exploration of questions about the relationship between neurochemistry and function, and the influence of anxiety on neurobiological findings in depression, in an integrative manner.