SKIN PROTEIN TURNOVER IN OLDER ADULTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。背景：衰老与特定的皮肤变化有关，这些变化增加了损伤的风险，如压疮，并延迟了伤口的愈合，从而使老年人的其他疾病的病程复杂化。皮肤老化既是由于年龄原因，也是由于长期暴露在阳光下。我们将重点关注不是由于阳光照射而引起的皮肤变化。具体目的和程序(摘要)：1)确定混合皮肤蛋白周转(合成和分解)是否可以作为人体真皮胶原蛋白周转(合成和分解)的替代指标。2)确定与年轻对照组相比，老年人的皮肤蛋白质合成是否更低和/或分解更快。实验设计(摘要)：志愿者将通过机构审查委员会批准的广告招募，该广告将在德克萨斯大学医学部、当地报纸和社会中心张贴，并通过口碑传播。我们将研究8名年轻男性(18-35岁)和8名老年男性(70岁)。意义(摘要)：我们希望了解健康年轻人的正常皮肤转换是什么，我们也希望了解皮肤转换是否会随着年龄的变化而变化。我们将测量年轻人和老年人的短期皮肤生长和分解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Aging is associated with specific skin changes that increase the risk of injury, such as pressure ulcers, and delay wound healing, thus complicating the course of other illnesses in seniors. Skin aging is due to both age and prolonged exposure to sunlight. We will focus on the skin changes that are not due to sunlight exposure. Specific Aims and Procedures (summary): 1) To determine if mixed skin protein turnover (synthesis and breakdown) can be used as alternative measures of dermal collagen protein turnover (synthesis and breakdown) in human subjects. 2) To determine if skin protein synthesis is lower and/or breakdown is faster in older individuals as compared to younger controls. Experimental Design (summary): Volunteers will be recruited by an institutional review board-approved advertisement that will be posted at the University of Texas Medical Branch, local newspapers, and social centers, and by word of mouth. We will study 8 younger (18 - 35 years) and 8 older (70 years) men. Significance (summary): We hope to learn what the normal skin turnover is in healthy younger people, and we also hope to learn if the skin turnover changes with age. We will measure short-term skin growth and breakdown in younger and older people.