INBRE: WINTHROP U: FACULTY & UNDERGRADUATE RESEARCH DEVELOPMENT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。认识到改善南卡罗来纳州公民健康的迫切需要，作为该州第二大PUI， Winthrop大学建议建立一个独特的生物医学研究项目，重点关注主要的人类健康问题。在接下来的五年里，温斯洛普将投入170万美元的自有资金来实现这一目标。温斯洛普提出了六个研究项目，重点是：1)研究心脏组织损伤的修复机制，2)研究前列腺癌中调节血管生成和细胞运动的潜在机制，3)开发新的光谱工具以更好地了解生命系统中金属和分子之间的广泛特定相互作用，4)完成最近与肥胖发展有关的蛋白质的结构分析，5)通过识别对这些过程至关重要的分子区域，揭示致癌蛋白在癌症进展中的特定作用；6)利用生物信息学技术预测乙型肝炎病毒的进化途径。这六个项目将得到以下方面的支持：1)一个生物医学核心实验室设施，其中包括四个新的工作人员科学家职位；2)有针对性的指导，提供援助、建议和资源，以实现单个项目的目标。温斯洛普?分子生物医学的重点为学生提供了一个多学科的视角，支撑和跨越了南卡罗来纳再生医学的努力范围。在对人类疾病过程的分子理解方面取得的进展，为解决影响人类健康的关键问题提供了取得重大进展的潜力。温斯洛普?S的重点提供了项目之间的巨大重叠，培养学生的多学科环境，以及强大的实验室核心的协同发展。温斯洛普的具体目标是什么？的程序是：1)大幅扩大生物医学研究能力，2)提高教师获得外部生物医学研究资金的竞争力，3)建立强大的生物医学研究基础设施支持核心，4)通过建立化学-生物综合生物医学科学课程，为学生提供强大的生物医学科学跨学科基础和生物医学研究经验。5)增加进入生物医学研究领域的生物学和化学毕业生的数量和比例；6)从代表性不足的群体中招募、培训和指导温斯洛普学院众多当前和未来的学生，以增加温斯洛普学院女性和少数族裔毕业生进入生物医学研究专业的数量和比例。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recognition of the critical need to improve the health of South Carolina's citizens and as the State's second largest PUI, Winthrop University proposes to establish a distinctive biomedical research program to focus on major human health concerns. Over the next five years, Winthrop will invest $1.7 million of its own funds to accomplish this goal. Winthrop proposes six research projects focusing on: 1) examining repair mechanisms for cardiac tissue damage, 2) investigating potential mechanisms that regulate angiogenesis and cell motility in prostate cancer, 3) developing new spectroscopic tools to better understand a wide range of specific interactions between metals and molecules in living systems, 4) completing the structural analysis of a protein recently implicated in obesity development, 5) revealing the specific role that oncogenic proteins play in cancer progression by identifying the molecular regions that are critical to these processes, and 6) using bioinformatic techniques to project evolutionary pathways of the Hepatitis B virus. These six projects will be supported by: 1) a biomedical core laboratory facility that includes four new staff scientist positions and 2) targeted mentorship to provide assistance, advice, and resources to meet individual project goals. Winthrop?s molecular biomedical focus provides students with a multidisciplinary perspective that underpins and spans the range of South Carolina's regenerative medicine efforts. Advances in a molecular understanding of human disease processes provide the potential for significant progress in addressing critical problems affecting human health. Winthrop?s focus provides tremendous overlap among projects, a multidisciplinary environment for training of students, and the synergistic development of a strong lab core. The specific objectives of Winthrop?s program are to: 1) dramatically expand biomedical research capacity, 2) increase the competitiveness of faculty for external biomedical research funding, 3) establish a strong biomedical research infrastructure support core, 4) provide students with a strong interdisciplinary foundation in the biomedical sciences and with experience in biomedical research through the establishment of an integrated chemistry-biology biomedical science curriculum, 5) increase the number and the percentage of biology and chemistry graduates that enter biomedical research fields, and 6) recruit, train, and mentor Winthrop's many current and future students from underrepresented groups to increase the number and the percentage of Winthrop female and minority graduates that enter the biomedical research profession.