COBRE: UAF: CANHR EPIDEMIOLOGY & BIOINFORMATICS CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。CANHR的一个迫切需要是在科学研究设计、实施和分析方面提供强有力的支持，开发和扩大资助研究。流行病学和生物信息学(EB)核心通过咨询和培训、研究设计或数据库(DB)开发、样本量/威力估计和数据分析，为研究项目提供科学和技术资源。此外，EB核心还提供技术支持，如计算机硬件/软件、数据输入和实地工作准备。第五年的成就包括：a.为三个研究项目的数据建立了四个数据库，并对参与者的反馈进行了评价。为了提高研究人员通过网络访问研究数据的安全性，我们正在从Access数据库改为使用SQL数据库。B.实用程序的开发使我们能够轻松地合并和传输数据以进行统计分析。由于提供了有效的数据库、实用程序和额外招聘的硕士级统计员，因此可以继续对报告进行常规生物统计分析，并为研究数据的分析提供统计专业知识。C.在一个新村庄开展和管理数据收集工作(村庄定位、招募和数据收集)。第二波数据收集是在我们原来的三个村庄进行的。这些努力包括与当地实地研究助理和村长/长老密切合作。D.向一个村庄的传统理事会和社区成员传播初步研究结果。个别实验室结果和其他卫生措施通过信件分发给参与者，社区内有卫生专业人员可供咨询。初步研究结果还在伯特利提交给育空-库斯科维姆保健公司和村长参加一年一度的部落会议。目前的工作：用于传播的数据分析、赠款申请的初步结果、科学文章、扩展家谱的连锁分析。此外，EB核心还为赠款申请提供统计咨询。目前正在两个新村庄进行数据收集工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A critical need for CANHR is to develop and expand funded research with strong support in scientific study design, conduct, and analysis. The Epidemiology and Bioinformatics (EB) Core provides both scientific and technical resources for the research projects through consultation and training, study design or database (DB) development, sample size/power estimates, and data analyses. In addition, the EB Core offers ¿technical support,¿ such as computer hard/software, data entry, and fieldwork preparation. Year five accomplishments include: A. Establishment of four databases for data from the three research projects and the participant feedback evaluation. To increase security and access to the research data over the web by researchers, we are in the process of changing from an Access database to one using sql. B. The development of ¿utility programs¿ allows us to easily merge and transfer data for statistical analysis. The availability of functioning databases, utility programs, and the additional recruitment of a master's level statistician make it feasible to continuously perform routine biostatistical analyses for reports and provide statistical expertise for the analysis of the research data. C. Conducted and managed data collection efforts (village orientation, recruitment, and data collection) in one new village. Second wave data collection was conducted in three of our original villages. These efforts involved close collaboration with local field research assistants and village leaders/elders. D. Dissemination of preliminary research findings to the traditional council and community members in one village. Individual laboratory results and other health measures were disseminated via letters to participants, with a health professional available in the community for consultation. Preliminary research findings were also presented in Bethel to the Yukon-Kuskokwim Health Corporation and village leaders at the annual Tribal Gathering. Current efforts: Data analyses for dissemination, preliminary results for grant applications, scientific articles, linkage analyses of extended pedigrees. In addition, the EB Core provides statistical consulting for grant applications. Data collection efforts in two new villages are being conducted.