LEAD AND CADMIUM AND KIDNEY DISEASE PROGRESSION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在项目5中，Muntner研究慢性铅暴露和肾脏疾病。在过去的20年里，关于铅暴露与慢性肾衰竭之间的关系一直存在很多争论。最近的研究是一项单中心病例对照研究，包括接受透析的终末期肾病患者和无肾衰竭的对照组。研究参与者是从杜兰大学透析诊所和新奥尔良路易斯安那州医学中心内科和家庭医学诊所招募的。所研究的主要接触是通过x射线荧光评估人体铅负荷。其他需要研究的暴露包括：血铅水平、尿镉排泄和踝肱指数。还将收集混杂变量的数据，包括血压、体重指数、教育、收入、职业和吸烟情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For Project 5, Muntner researches the study of chronic lead exposure and kidney disease. There has been much debate over the past 20 years regarding the relationship between lead exposure and chronic renal failure. The recent study was a single center case-control study including patients with end-stage renal disease receiving dialysis and controls without kidney failure. Study participants are being recruited from the Tulane University dialysis clinics and Medical Center of Louisiana at New Orleans internal medicine, and family medicine clinics. The primary exposure being studied is body lead burden assessed through X-ray fluorescence. Other exposures to be studied include: blood lead levels, urinary cadmium excretion, and ankle brachial index. Data on confounding variables including blood pressure, body mass index, education, income, occupation, and cigarette smoking will also be collected.