INFLUENCE OF MELATONIN ON NEUROREGENERATION IN CRUSTACEANS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该试点项目的目的是建立一个监测甲壳类动物神经突生长的模型系统，并在细胞和分子水平上研究褪黑激素对这一过程的影响。褪黑激素影响脊椎动物大脑区域的神经突生长和功能，尽管其机制尚不清楚。甲壳类动物为各种生物医学研究提供了强大的类似系统。在项目的第一年，我们确定了可以培养的细胞类型，以提供神经突生长的测定。这些细胞来自x器官，一种甲壳动物眼柄中的神经分泌结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this pilot project are to establish a model system for monitoring neurite outgrowth in crustaceans and to study the influence of melatonin at the cellular and molecular levels on this process. Melatonin affects neurite growth and function in regions of the vertebrate brain, though the mechanisms are not yet known. Crustaceans provide robust and analogous systems for a variety of biomedical studies. In the first year of the project, we identified cell types that could be cultured to provide an assay for neurite growth. These cells came from the x-organ, a neurosecretory structure in the crustacean eyestalk.