Filtered eyewear to prevent light-induced melatonin suppression while maintaining visual performance and alertness in night-shift working nurses

过滤眼镜可防止光引起的褪黑激素抑制,同时保持夜班护士的视觉表现和警觉性

基本信息

项目摘要

Project Summary/Abstract. The suppression of melatonin production by nighttime retinal light exposure has been linked to health risks to nightshift workers. Blue-blocking filters can preserve nighttime melatonin levels, and monocular light exposures can radically reduce nighttime melatonin suppression to as little as 10% of that observed for conventional binocular exposures. Our premise is that positioning a blue-blocking orange filter over one eye will preserve binocular vision while reducing light-induced melatonin suppression relative to a completely unfiltered viewing condition. This solution should not impede the performance of visual tasks that might require binocular vision, nor should it cause user discomfort. We propose a laboratory experiment (Aim 1) to determine whether blue- blocking filters and monocular viewing, alone or in combination, are effective for maintaining melatonin at night without affecting visual performance and subjective sleepiness (KSS). Aim 2 will be conducted at the Simulation Teaching and Research Center (STAR) at the Icahn School of Medicine at Mount Sinai to determine whether altered viewing interventions could influence melatonin levels and simulated task performance requiring depth perception (e.g., catheter / intra venous insertion in dummy) in healthcare workers. For Aim 3, involving nightshift working workers operating in actual hospital environments at Mount Sinai Hospital and Memorial Hospital in South Bend, IN, we will determine whether eyewear aimed at maintaining melatonin at night would be effective, practical, and socially acceptable. Aim 1 will employ a crossover within-subjects design, exposing subjects to 6 experimental conditions (monocular/binocular x filtered/non-filtered, 2 controls) over the course of 6 independent sessions. Aim 2 will employ a within-subjects design exposing subjects to 4 experimental conditions (control, filtered binocular, filtered monocular, unfiltered monocular/dominant eye occluded) over the course of 4 nightshifts (separated by at least a week). Aim 3 will be employ a within-subjects design similar to Aim 2 over the course of 4 one-week sessions (at least 3 shifts per session) with salivary melatonin levels, sleepiness scores, and Likert scale responses, as the output measures. This proposal is significant from a practical perspective because the methods to be tested could serve as elegant, inexpensive, personalized, non-invasive optical interventions to protect the natural synthesis of melatonin in night-shift workers. We will be addressing Healthy Work Design and Well-being (cross-sector). As part of the Research to Practice (r2p) activity, we will address need to maintain melatonin at night among nightshift nurses with a novel, but inexpensive technology, and evaluate its efficacy in practice.
项目概要/摘要。 夜间视网膜光暴露对褪黑激素产生的抑制与健康风险有关, 夜班工人蓝光过滤器可以保持夜间褪黑激素水平, 可以从根本上减少夜间褪黑激素的抑制,只有传统方法的10%。 双眼曝光我们的前提是,在一只眼睛上放置一个蓝色阻挡橙子过滤器将保留 双眼视觉,同时相对于完全未过滤的观看减少光诱导的褪黑激素抑制 条件这种解决方案不应妨碍可能需要双目视觉的视觉任务的执行, 也不应引起使用者的不适。我们提出了一个实验室实验(目标1),以确定是否蓝- 单独或结合使用阻挡滤光片和单眼观察,对于在夜间维持褪黑激素是有效的 而不影响视觉表现和主观嗜睡(KSS)。目标2将在模拟中进行 西奈山伊坎医学院的教学和研究中心(星星),以确定是否 改变观察干预可能会影响褪黑激素水平和需要深度的模拟任务表现 感知(例如,导管/假人静脉内插入)。对于目标3, 在西奈山医院和纪念医院的实际医院环境中工作的夜班工人 在印第安纳州南本德的一家医院,我们将确定旨在维持夜间褪黑激素的眼镜是否 要有效、实用,并为社会所接受。目标1将采用交叉受试者内设计, 受试者在整个过程中接受6种实验条件(单眼/双眼x滤过/非滤过,2个对照) 6次独立会议。目标2将采用受试者内设计,将受试者暴露于4个实验 条件(对照、滤过性双眼、滤过性单眼、未滤过性单眼/优势眼遮挡) 4个夜班的课程(至少间隔一周)。目标3将采用类似的受试者内设计 目标2在4个为期一周的疗程(每个疗程至少3个班次)中,唾液褪黑激素水平, 嗜睡评分和李克特量表反应,作为输出测量。这一建议从实际意义上讲, 因为要测试的方法可以作为优雅,廉价,个性化,非侵入性的 光学干预措施可保护夜班工人褪黑激素的自然合成。我们将致力于 健康的工作设计和福祉(跨部门)。作为研究实践(r2 p)活动的一部分,我们将 用一种新颖但廉价的技术解决夜班护士在夜间维持褪黑激素的需求, 并在实践中评估其有效性。

项目成果

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Mariana Gross Figueiro其他文献

Mariana Gross Figueiro的其他文献

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{{ truncateString('Mariana Gross Figueiro', 18)}}的其他基金

Supporting health equity with bias-free pulse oximetry
通过无偏差脉搏血氧测定法支持健康公平
  • 批准号:
    10701873
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
  • 批准号:
    10516569
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
  • 批准号:
    10668466
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
  • 批准号:
    10392164
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
  • 批准号:
    10670054
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Supporting health equity with bias-free pulse oximetry
通过无偏差脉搏血氧测定法支持健康公平
  • 批准号:
    10571419
  • 财政年份:
    2022
  • 资助金额:
    $ 67.37万
  • 项目类别:
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
昼夜节律不同步引起的糖尿病和动脉粥样硬化疾病的时钟调节 - 机制和干预措施
  • 批准号:
    10454373
  • 财政年份:
    2021
  • 资助金额:
    $ 67.37万
  • 项目类别:
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
为痴呆症患者量身定制光疗的方法学问题
  • 批准号:
    10320581
  • 财政年份:
    2021
  • 资助金额:
    $ 67.37万
  • 项目类别:
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
为痴呆症患者量身定制光疗的方法学问题
  • 批准号:
    10570263
  • 财政年份:
    2021
  • 资助金额:
    $ 67.37万
  • 项目类别:
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
昼夜节律不同步引起的糖尿病和动脉粥样硬化疾病的时钟调节 - 机制和干预措施
  • 批准号:
    10622428
  • 财政年份:
    2021
  • 资助金额:
    $ 67.37万
  • 项目类别:

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