UKY DENTAL COBRE: DENTAL CLINICAL RESEARCH CENTER

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。DDKCRC的主要重点是创建一个研究基础设施：1）开发和培训临床研究专业人员，研究协调员和研究人员，2）定义和影响肯塔基州农村社区的口腔健康差异。最初的重点将是调查，以确定这些农村人口的口腔系统疾病的联系，并确定生物，遗传和社会行为因素，这些差异。DDKCRC人员专注于为中心项目4、5和6编制和提交IRB批准表格。这些都已获得，项目也已启动。这些工作人员为这些项目招募病人以及为这些项目收集生物标本作出了贡献。此外，该中心亦会支援阿尔茨海默病先导计划的临床研究需要。的疾病（斯坦博士）和新的吸烟基因型的完整项目（Al-Sabbagh博士）。最后，DDKCRC的实验室人员为项目2、4、5和6的宿主分析物评价提供了支持。此外，实验室还开发了一种实时定量PCR方法，用于评估龈下菌斑中的目标微生物，从而改善了项目4、5和6中微生物变化的评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A primary focus of the DDKCRC is to create a research infrastructure to: 1) develop and train clinical research professionals, research coordinators, and research staff and 2) define and impact oral health disparities in rural communities of Kentucky. An initial emphasis will be on investigations to determine oral-systemic disease linkages in these rural populations, and to define biological, genetic, and socio-behavioral factors contributing to these disparities. The DDKCRC personnel have focused on the preparation and submission of forms for IRB approval for Projects 4, 5 and 6 for the center. These have all been obtained and the projects initiated. The personnel have contributed to the recruitment of patients for these same projects, as well as collecting biological specimens for the projects. In addition, the DDKCRC will be supporting the clinical research needs of the Pilot Project on Alzheimer?s Disease (Dr. Stein) and the new full project on Smoking Genotypes (Dr. Al-Sabbagh). Finally, the laboratory personnel in the DDKCRC, have provided support for evaluation of host analytes for Projects 2, 4, 5, and 6. In addition, the laboratory has developed a real-time quantitative PCR methodology for assessment of target microorganisms in the subgingival plaque allowing improved evaluation of microbial changes in Projects 4, 5 and 6.