Heat Shock Transcription Factors in Bone Remodeling and Disease

骨骼的密度是精细平衡的，是健康生活方式所必需的。在疾病、损伤或药物治疗期间，骨骼可能受到损害，通常密度下降，变得脆弱。这通常会导致骨折、疼痛和生活质量下降。这项提议旨在调查压力对骨骼的损害是否在骨质流失中起作用。这将为疾病期间的骨质流失提供新的见解，并导致新的治疗策略。

The denisity of bone is finely balaned and required for a healthy lifestyle. During times of disease, damage or drug treatments the bone can be compromised, often decreasing in density and becoming fragile. This often leads to fractures, pain and a poor quality of life. This proposal seeks to investigate whether stress insults to bones plays a role in the loss of bone. This will provide new insights into bone loss during disease and lead to novel treatment strategies.