DEVELOPMENT OF AN SPF MACACA NEMESTRINA BREEDING COLONY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述（由申请人提供）：长尾猕猴（Macaca nemestrina）在所有医学研究领域的使用已经增加到供不应求的地步，生物恐怖主义研究活动的增加无疑会在不久的将来增加对非人类灵长类动物的需求。由此导致的价格上涨和购买猴子的延迟，阻碍了进行资助研究的能力。许多领域的研究人员在进行研究的能力方面都经历过类似的中断。这项申请的主要目的是开发一种新的国家资源，为全国各地的研究人员提供SPF长尾猕猴。资源相关研究还将通过开发免疫学研究的关键试剂，进一步提高长尾猕猴作为研究模型的有效性。长尾猕猴被广泛用于各种医学研究。艾滋病研究是对长尾猕猴供应的最新需求，但在过去的5年里，用长尾猕猴进行的已发表的研究中有75%是在非艾滋病研究领域。矛盾的是，随着对长尾猕猴需求的增加，商业繁殖来源却减少了产量。科文斯，解散了他们的长尾猕猴繁殖计划，弗吉尼亚州的实验室减少了三分之一的繁殖种群。耶基斯和华盛顿国家灵长类动物研究中心(WaNPRC)/杜兰NRPRC和新伊比利亚灵长类动物研究中心是仅有的拥有大规模长尾猕猴繁殖计划的机构。尽管最近它们的繁殖能力有所提高，万洲中心的官员表示，他们将无法满足目前和预期的研究对长尾猕猴的需求。这项申请的资金将使现有的种群继续扩大到大约125只繁殖年龄的雌性，每年产生足够的动物来维持繁殖群，并产生大约62个后代。在这样一个规模的群体中，50%的雄性后代将以市场价出售给约翰霍普金斯大学以外的研究人员。对美国国立卫生研究院资助的长尾猕猴的需求已经超过了目前的供应。必须发展新的国家研究基础设施，以帮助满足现有和未来的研究需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The use of pig-tailed macaques (Macaca nemestrina) in all areas of medical research has increased to the point that demand exceeds supply and increased research activity in bioterrorism will undoubtedly increase the demand for nonhuman primates in the near future. The resulting increased prices and increased delays in procuring monkeys hinder the ability to conduct funded research. Researchers in many fields have experienced similar disruptions in their ability to conduct research. The primary objective of this application is to develop a new national resource that will supply SPF pig-tailed macaques to researchers across the country. The proposed resource-related research would also further the usefulness of the pig-tailed macaque as a research model through the development of key reagents for research in the immunology. Pig-tailed macaques are used in a wide variety of medical research. AIDS research is the newest demand on the supply of pig-tailed macaques, but in the last 5 years, 75% of published studies with pig-tailed macaques have been in non-AIDS research areas. As demand for pig-tailed macaques has increased, paradoxically, commercial breeding sources have declined production. Covance, disbanded their pig-tailed macaque breeding program, and LABS of Virginia reduced their breeding stock by one third. The Yerkes and Washington National Primate Research Centers (WaNPRC)/Tulane NRPRC and the New Iberia Primate Research Center are the only facilities with a sizable pig-tailed macaque breeding program. Despite recent increases in their breeding capacity, officials at WaNPRC indicate that they will not be able to meet the current and expected demand for pig-tailed macaques in research. Funding of this application will allow the continued expansion of an existing colony to approximately 125 breeding-age females yielding enough animals to maintain the breeding stock and produce approximately 62 offspring each year. With a colony this size, 50% of the male offspring would be made available for sale at market prices to researchers outside of the Johns Hopkins University. Demand for pig-tailed macaques from NIH funded grants already exceeds current supplies. New national research infrastructure must be developed to help meet existing and future research demands.