Development of an SPF Macaca nemestrina Breeding Colony

描述（由申请人提供）：在医学研究的所有领域中，猪尾猕猴（Macaca nemestrina）的使用已经增加到供不应求的程度，生物恐怖主义研究活动的增加无疑将在不久的将来增加对非人灵长类动物的需求。由此导致的价格上涨和采购猴子的延误增加阻碍了开展资助研究的能力。许多领域的研究人员在进行研究的能力方面都经历过类似的中断。这项申请的主要目的是开发一种新的国家资源，为全国各地的研究人员提供SPF猪尾猕猴。拟议的资源相关研究还将通过开发免疫学研究的关键试剂，进一步提高猪尾猕猴作为研究模型的实用性。猪尾猕猴被用于各种各样的医学研究。艾滋病研究是对猪尾猕猴供应的最新需求，但在过去5年中，75%的已发表的猪尾猕猴研究都是在非艾滋病研究领域。自相矛盾的是，随着对猪尾猕猴需求的增加，商业饲养源的产量却下降了。科文斯，解散了他们的猪尾猕猴繁殖计划，弗吉尼亚州的实验室减少了三分之一的繁殖种群。耶基斯和华盛顿国家灵长类动物研究中心（WaNPRC）/杜兰NRPRC和新伊比利亚灵长类动物研究中心是唯一具有相当规模的猪尾猕猴繁殖计划的设施。尽管最近他们的繁殖能力有所增加，但WaNPRC的官员表示，他们将无法满足目前和预期的研究对猪尾猕猴的需求。这项申请的资金将使现有的殖民地继续扩大到大约125个繁殖年龄的女性产生足够的动物，以维持繁殖种群，每年产生大约62个后代。有了这样一个规模的群体，50%的雄性后代将以市场价格销售给约翰霍普金斯大学以外的研究人员。NIH资助的赠款对猪尾猕猴的需求已经超过了目前的供应。必须发展新的国家研究基础设施，以帮助满足现有和未来的研究需求。

DESCRIPTION (provided by applicant): The use of pig-tailed macaques (Macaca nemestrina) in all areas of medical research has increased to the point that demand exceeds supply and increased research activity in bioterrorism will undoubtedly increase the demand for nonhuman primates in the near future. The resulting increased prices and increased delays in procuring monkeys hinder the ability to conduct funded research. Researchers in many fields have experienced similar disruptions in their ability to conduct research. The primary objective of this application is to develop a new national resource that will supply SPF pig-tailed macaques to researchers across the country. The proposed resource-related research would also further the usefulness of the pig-tailed macaque as a research model through the development of key reagents for research in the immunology. Pig-tailed macaques are used in a wide variety of medical research. AIDS research is the newest demand on the supply of pig-tailed macaques, but in the last 5 years, 75% of published studies with pig-tailed macaques have been in non-AIDS research areas. As demand for pig-tailed macaques has increased, paradoxically, commercial breeding sources have declined production. Covance, disbanded their pig-tailed macaque breeding program, and LABS of Virginia reduced their breeding stock by one third. The Yerkes and Washington National Primate Research Centers (WaNPRC)/Tulane NRPRC and the New Iberia Primate Research Center are the only facilities with a sizable pig-tailed macaque breeding program. Despite recent increases in their breeding capacity, officials at WaNPRC indicate that they will not be able to meet the current and expected demand for pig-tailed macaques in research. Funding of this application will allow the continued expansion of an existing colony to approximately 125 breeding-age females yielding enough animals to maintain the breeding stock and produce approximately 62 offspring each year. With a colony this size, 50% of the male offspring would be made available for sale at market prices to researchers outside of the Johns Hopkins University. Demand for pig-tailed macaques from NIH funded grants already exceeds current supplies. New national research infrastructure must be developed to help meet existing and future research demands.