Regional Biocontainment Laboratory (RBL)

描述（由申请人提供）：杜克RBL的总体主题将是为研究选定病原体和新兴感染的宿主防御和微生物发病机制提供设施，重点是在第四区域生物防御和新兴感染卓越区域中心（RCE）进行的工作。杜克RBL将提供一个最先进的BSL-2/BSL-3生物防护设施，该设施将拥有研究核心和实验室，以研究选定病原体和新出现的感染的细胞和分子生物学，并提供一个中心位置，使整个杜克大学和该地区的研究人员的活动集中在选定病原体的基础和转化研究上。杜克大学之前30年的历史中有一个NIH建造的现场生物防护设施（癌症中心隔离设施），再加上杜克大学作为总部和领导机构的区域四东南地区卓越中心在生物防御和新兴感染（SERCEB），是这个RBL应用的重要优势。杜克RBL的建设将确保第四区域RCE的主要组成部分能够实现为选定的病原体开发疫苗、药物和疫苗的目标。

DESCRIPTION (provided by applicant): The overall theme of the Duke RBL will be provision of facilities for the study of host defense and microbial pathogenesis of select agents and emerging infections with emphasis on work performed in the Region IV Regional Center of Excellence For Biodefense and Emerging Infections (RCE). The Duke RBL will provide a state-of-the-art BSL-2/BSL-3 biocontainment facility that will have research cores and laboratories to study the cell and molecular biology of select agents and emerging infections, and provide a central location that will focus the activities of investigators throughout Duke University and the region on select agent basic and translational research. Duke's prior 30-year history of having an NIH-built biocontainment facility on site (the Cancer Center Isolation Facility), coupled with Duke University as the headquarters and lead institution for the Region IV Southeast Regional Center of Excellence in Biodefense and Emerging Infections (SERCEB), are important strengths of this RBL application. Construction of the Duke RBL will ensure that a major component of the Region IV RCE will be able to meet the goals of developing vaccines, drugs and vaccines for select agents.