Intraoperative 3T MRI Scanner for Minimally Invasive Therapy

描述（由申请人提供）：我们建议购买一套独特的介入磁共振成像系统，用于开发最先进的微创治疗图像引导技术。集成仪器系统包括高性能临床MRI扫描仪、多模态手术台、术中成像模式和导航系统，以支持布里格姆妇女医院（BWH）和朗伍德医疗区内邻近机构的新研究和正在进行的研究。这是一个由GE医疗集团开发的最先进的系统，作为未来手术室计划的核心。如果获得资助，该仪器系统将帮助我们在开放手术、微创经皮治疗、血管介入和肿瘤热消融（包括革命性的无创MRI引导聚焦超声技术）中实现多模态导航技术的图像引导。在过去的十年中，BWH的研究小组在图像引导治疗领域发挥了先锋作用，并开发了一个包括五个独立领域的项目：磁共振治疗，手术计划，肿瘤消融，核磁共振引导聚焦超声，生物工程和成像。这些领域的基础临床研究已经发展成为高度多学科的活动，其中技术和专业知识是共享的；模式结合；并且应用被转移到外科领域和解剖系统。我们现在正在将我们的研究结合到一个新的集成系统和一个新的范例中，其中几种先进的成像模式（包括MRI， x射线透视，PET-CT和3D超声），导航工具和新的图像引导治疗递送系统将被集成。我们已经汇集了超过12个NIH资助的研究项目，3个NIH中心和30个当地研究者和合作者，他们将直接受益于拟议的仪器。除此之外，我们还在审查一些关键的拨款提案，以及一些外部资助的项目和合作，这些项目和合作将受益于这种高端仪器。有了这项研究的支持，在图像引导治疗方面的良好记录，以及强有力的机构承诺，我们准备部署一个配备了最先进的介入成像系统的手术室，以开发新的治疗方法。

DESCRIPTION (provided by applicant): We propose the purchase of a unique Interventional Magnetic Resonance Imaging system for developing state-of-the-art image-guidance techniques for minimally-invasive therapies. The integrated instrumentation system includes a high-performance clinical MRI scanner, a multi-modality surgical table, intraoperative imaging modalities, and navigation systems to support new and ongoing research at the Brigham and Women's Hospital (BWH) and adjacent institutions located within the Longwood Medical area. This is a tate-of-the art system that has been developed by GE Healthcare as the core of an initiative called the Operating Room of the Future. If funded, this instrument system will help us to implement multi-modality navigational techniques for image-guidance during open surgeries, minimally invasive percutaneous therapies, vascular interventions, and thermal ablation of tumors (including a revolutionary non-invasive MRI- guided focused ultrasound technology). Over the past decade, research groups at BWH have played a pioneering role in the field of Image-Guided Therapy and have developed a program comprising five discrete areas: Magnetic Resonance Therapy, Surgical Planning, Tumor Ablation, MRI-guided Focused Ultrasound, and Bioengineering and Imaging. Basic Clinical Research in these areas has evolved into highly multidisciplinary activities wherein technology and expertise are shared; modalities are combined; and applications are transferred across surgical domains and anatomical systems. We are now combining our research into a new integrated system and a new paradigm where several advanced imaging modalities (including MRI, X-Ray fluoroscopy, PET-CT and 3D ultrasound), navigational tools and novel image-guided therapy delivery systems will be integrated. We have assembled a portfolio of more than 12 NIH funded research projects, 3 NIH Centers, and 30 local investigators and collaborators who will directly benefit from the proposed instrumentation. In addition to this, we have a number of key grant proposals under review and several externally funded projects and collaborations that will benefit from access to this high-end instrumentation. With this research support, a proven track-record in image-guided therapy, and a strong institutional commitment, we are uniquely prepared to deploy an operating room equipped with a state-of- the-art interventional imaging system in order to develop novel therapies.