HIPPOCAMPAL FORMATION IN PSYCHOPATHY: A RADIAL MAPPING MR-BASED STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。的背景。精神病的神经生物学仍然很模糊。内侧颞叶病理被认为是神经系统功能障碍的一部分，表现为暴力和精神病行为。在之前的一项研究中，Laakso和他的同事利用磁共振测量了海马区域的体积，发现海马前后轴的区域体积与受试者的精神病态程度相关。双侧海马后半区与精神病态得分呈显著负相关。的目标。在体内定位精神病患者海马结构的变化。方法。本研究包括26名男性精神病患者（年龄：32¿8）和25名对照组（35¿11）。使用《精神病检查表-修订版》对精神病进行评估。在注册到一个共同的立体定向空间后，通过在35个冠状面切片上手工追踪海马本体和下托的轮廓来分离海马结构。组的差异将评估算法开发特设，利用三维参数表面网格模型。预期的结果。我们预计，在精神病患者和对照组之间，海马体形成的区域差异应该存在，并且应该与先前通过体积测量获得的结果一致（Laakso et al, 2001）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background. Neurobiology of psychopathy remains obscure. Medial temporal lobe pathology has been suggested to be a part of the neural systems dysfunction which manifests as violent and psychopathic behavior. In a previous study, Laakso and colleagues measured regional hippocampal volumes using magnetic resonance and found that the regional volumes along the anteroposterior axis of the hippocampus were correlated with the subjects' degree of psychopathy. Strong negative correlations were observed between the psychopathy scores and the posterior half of the hippocampi bilaterally. Aim. To locate in vivo the structural changes within the hippocampal formation in subjects with psychopathy. Methods. Twenty-six men with psychopathy (age:32¿8) and 25 controls (35¿11) were included in this study. Psychoapthy were assessed using the Psychopathy Checklist-Revised. The hippocampal formation will be isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences will be assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. Expected results. We expect that regional differences within the hippocampal formation should exist between psychopathy and controls and should be in line with previous results obtained with volumetric measurements (Laakso et al, 2001).