Research Training in Pediatric Critical Care Medicine

描述(由申请人提供)：儿科重症监护医学是一个快速发展的，但相对较新的子专业。显然，需要增加儿科危重护理医学领域的学术内科科学家，并合作严格调查新的治疗方式，重点放在病理生物学和长期发病率上。这是一项在加州大学旧金山分校儿科系内建立儿科危重护理医学博士后研究培训计划的建议。该提案的目标是增加训练有素、成功资助和可持续发展的儿科重症监护医生-科学家的数量，他们将进行高水平的实验室和/或临床转化研究，最终提高我们对危重疾病病理生物学的理解，改善短期和长期结果，并减少残留残疾和/或慢性病儿童的发生率。为此，该计划旨在为拥有医学博士或医学博士/博士学位的儿科医生提供全面的科学培训和职业发展指导，这些医生致力于具有强大研究成分的学术事业。拟议培训方案的关键要素是(1)有指导的研究经验，(2)科学课程工作，(3)职业发展研讨会，(4)跨学科经验，(5)持续审查和评估。该计划的核心是建立一个为期4年的奖学金培训计划，其中两年致力于基础实验室科学、临床-翻译科学或与儿科危重疾病相关的流行病学方面的强化研究培训。大量非常合格的教职员工承诺为拟议的培训补助金支持的研究员提供指导。这些教师隶属于加州大学旧金山分校的几个校区，并组织了研究单位和项目，代表了加州大学旧金山分校实验室研究人员和临床研究人员之间的强烈互动。此外，这些附属机构的资源，包括心血管研究所、流行病学和生物统计学系、生物医学科学计划、生物科学计划、几个加州大学旧金山分校的临床校区和奥克兰儿童医院，都对学员开放。所有研究员将参加(1)负责任的研究行为、(2)科学写作和(3)讲课艺术的课程。研究员和他们的导师根据申请者以前的经验和培训以及受训者研究的科学主题，计划一项额外的特定学科的课程工作。加州大学旧金山分校有跨学科调查和教育的传统。研究员将通过参加由跨学科项目赞助的许多研讨会系列、期刊俱乐部和研讨会来扩大他们在自己学科内和跨学科的教育。学员指导计划将支持博士后研究员的培训和职业发展。研究员在参加培训时将与三名教师导师配对；导师将定期与研究员会面，每年不少于两次，以协助他/她制定和监测培训和职业目标。儿科和重症监护医学部在招募和培训儿科分科专家方面有着良好的记录，我们的毕业生在儿科学术领域取得了持续的成就。因此，该计划的基本原理是基于对精心设计的培训计划的充分证明的需求，以使儿科科学家为在儿科危重护理研究中持续的富有成效的职业生涯做好准备，以及加州大学旧金山分校的儿科部门拥有培训下一代儿科科学领导者的愿景、经验和基础设施。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine is a rapidly growing, yet relatively new subspecialty. The need for increased academic physician-scientists in Pediatric Critical Care Medicine, and collaborative rigorous investigation of new treatment modalities with focus on pathobiology and long-term morbidities is clear. This is a proposal to establish a post-doctoral research training program in Pediatric Critical Care Medicine within the Department of Pediatrics at the University of California, San Francisco. The goal of the proposal is to increase the number of highly trained, successfully funded and sustainable pediatric critical care physician-scientists, who will perform high level laboratory and/or clinical-translational research that will ultimately improve our understanding of the pathobiology of critical illness, improve short and longterm outcomes, and reduce the incidence of children with residual disabilities and/or chronic disease. To this end, this program aims to provide comprehensive science training and mentoring career development for pediatricians with an M.D. or M.D./Ph.D. degree who commit themselves to an academic career with a strong research component. The key elements of the proposed training program are (1) a mentored research experience, (2) scientific course work, (3) career development workshops, (4) interdisciplinary experiences, (5) continuing review and evaluation. The centerpiece of the program is the establishment of a 4-year fellowship training program, with two years devoted to intense research training in basic laboratory science, clinical-translational science, or epidemiology related to pediatric critical care disease. A large number of exceptionally qualified faculty have committed their support as mentors for fellows supported by the proposed training grant. The faculty are affiliated with several of the UCSF campuses and organized research units and programs, and are representative of the strong interaction between laboratory-based investigators and clinical investigators at UCSF. In addition, the resources of these affiliations, which include the Cardiovascular Research Institute, the Department of Epidemiology and Biostatistics, the Biomedical Science Program, the Program in Biological Sciences, several UCSF clinical campuses, and Oakland Children's Hospital, are all available to the trainees. All fellows will take courses in (1) Responsible conduct in research, (2) Scientific writing and (3) The art of lecturing. Fellows and their mentor plan a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee's research. UCSF has a tradition of interdisciplinary investigation and education. Fellows will broaden their education both within their discipline and across disciplines by attending a selection of the many seminar series, journal clubs, and workshops sponsored by the interdisciplinary programs. A Trainees Mentoring Program will support post-doctoral fellows in their training and career development. Fellows will be matched with three faculty mentors on entry into their training; the mentors will be available to meet with the fellow on a regular basis, and no less than twice a year, to assist him/her in setting and monitoring training and career goals. The Department of Pediatrics and the Division of Critical Care Medicine have a strong track record in recruiting and training pediatric sub-specialists, and our graduates have an excellent record of sustained accomplishments in academic pediatrics. Thus, the rationale for the program is based on the well documented need for well-designed training programs to prepare pediatric-scientists for a sustained productive career in Pediatric Critical Care research and the fact that the Department of Pediatrics at UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science.