Pre-doctoral Training Program in Integrative Vascular Biology

描述(由申请人提供)： 心血管疾病的发病机制是复杂的。然而，受过培训的研究人员处理整个生物体疾病的人数正在减少。因此，我们建议通过在博士前培训期间开始的多学科合作，培养未来的血管生物学家，能够实施结合“细胞”、“整个动物”和“人类”系统的综合方法。我们在北卡罗来纳大学开发了一个跨学科的综合血管生物学(IVB)博士前培训项目，其明确的目标是鼓励学生合作，并将他们团结成一个IVB小组。四年前由Curren T32资助开始的IVB方案迄今取得的成功是显而易见的，从从AHA和其他来源获得个人奖学金的学员数量(7/16)以及学员在各种会议上获得的旅行/海报奖(总计17个)中可以清楚地看到这一点。该项目还影响了北卡罗来纳大学校园的整体血管生物学研究。这份续签申请申请资金用于继续我们的IVB项目，每年支持15名博士前实习生。学员将从北卡罗来纳大学已经注册的系计划和课程的研究生中挑选出来，并将获得长达三年的支持。为了鼓励多学科的方法，我们要求每个学员除了传统的主要导师外，还必须有协作导师(S)。IVB项目由全校分子生物学和生物技术项目管理。病理学和实验室医学教授前田信洋博士是主任，遗传学教授马克·马杰斯基博士是联席主任。主要的论文导师是教师(来自北卡罗来纳大学三所学校和一所学院的12个系)，致力于通过分子、细胞和整个生物体水平的血管生物学相关研究进行博士前培训。为了组成一个辅助性的教员队伍，学员可以选择与之合作，初级培训机构由北卡罗来纳大学的临床教员和科学家加入，他们主要与博士后学生一起保持活跃的实验室，以及附近研究三角地区机构的研究人员。北卡罗来纳大学的IVB项目凭借其在血管生物学研究方面的杰出历史、强大的研究团队以及在动物模型研究方面的实力，为博士生预科学生的多学科培训提供了出色的环境。

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Yet the number of investigators trained to deal with whole organism diseases is decreasing. Accordingly, we propose to train future vascular biologists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems through multidisciplinary collaborations that begins during pre-doctoral training. We have developed an interdisciplinary program for predoctoral training in Integrative Vascular Biology (IVB) at the University of North Carolina with the stated goal of stimulating students to collaborate, and to unite them as an IVB group. The success of the IVB Program to date, which began four years ago with the curren T32 funding, is clearly, demonstrated by the number of trainees who went on to obtain individual fellowships from AHA and other sources (7/16) and of travel/poster awards earned by the trainees at various meetings (total 17). The program has also stimmulated overall vascular biology research on UNC campus. This renewal application requests a funding to continue our IVB Program with a support for 15 pre-doctoral trainees per year. Trainees will be selected from graduate students already enrolled in departmental programs and curricula at UNC, and will be suported for up to three years. To encourage the multi-disciplinary approach, we require each trainee to have collaborating advisor(s) in addition to the conventional primary mentor. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Professor of Pathology and Laboratory Medicine, is the Director, and Dr. Mark Majesky, Professor of Genetics, is the Co-Director. The primary thesis advisors are faculty members (from 12 Departments in three Schools and one College at UNC), with a strong commitment to predoctoral training through vascular biology related research at the molecular, cellular, and whole organism levels. To form a body of complementing faculty with whom the trainees can choose to collaborate, the primary training faclty is joined by clinical faculty and scientists at UNC, who maintain active laboratories mainly with postdoctoral students, and by investigators at nearby Institutions in the Research Triangle area. With its outstanding history in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an outstanding environment for multidisciplinary training of pre-doctoral students.