Enzyme Responsive Materials for Biology and Medicine

这项建议是为了开发合理设计生物医学应用的酶响应材料(ERM)的新途径。这些材料可以改变性质，例如，它们可以膨胀/崩溃，或者在生化反应中从溶液变成凝胶。这些材料可能在药物控制释放方面有应用，以响应疾病特定的酶。它们还可用于触发组装细胞生长的基质，并在组织工程中应用。该项目的成果将是：(I)新的交互生物材料的开发和全面表征；(Ii)加深对分子水凝胶结构/功能关系的基本了解；(Iii)用于3D细胞培养的酶触发支架组装的概念验证应用；以及(Iv)酶触发药物输送。

This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.