Admin. Core Interdepartmental Two-photon Imaging Center

中心核心的管理将分为三个部分：管理核心、成像 核心和指导委员会。行政核心将由一名核心顾问管理， 由行政人员协助（见下页图表）。核心顾问（22%的工作量）将负责 设备采购和与供应商谈判价格（特别是在多次采购可能使 管理行政人员，维持核心设备库存， 供应，安排指导委员会的定期会议，并担任指导委员会之间的联络， 委员会和核心董事。他还将负责监督系统改进项目， 与我们的企业合作伙伴和顾问协调活动，组织和完成 向NIH提交年度报告。 博士Hockberger，生理学2P成像核心主任和儿科2P核心顾问 和神经病学，已同意担任核心顾问。他一直活跃在光学生理学领域 25年来，他在树突状细胞Ca2+信号传导、分化的作用和细胞凋亡方面做出了开创性的贡献。 粘附在神经元迁移和寻路中的作用，以及活体光毒性的来源和治疗 细胞显微镜他一直负责开发成像资源（包括基于CCD和2P 成像），洛约拉大学（芝加哥），埃尔兰根大学（德国）和波恩大学 （德国）。他一直是国际光学工程师协会（SPIE）的积极参与者， 在过去的12年里，他一直是许多国家和国际研讨会的特邀演讲者。在NU，他 在研究生和博士后的定量方面的教育中发挥了主导作用， 生物成像自1992年以来，他指导了一门研究生课程（IGP 415：生物成像：原理和方法）。 应用），教授生命科学中定量图像分析的理论和实践。 每个成像核心将由一名核心主管管理。我们已经确定了适当的教师谁拥有 同意担任核心总监（见图表），他们的工作（5%）将由各自的部门分担。 主任将负责监督核心，就核心内的政策向用户提供咨询意见， 并跟踪核心使用情况。每位董事都将获得技术支持，以协助日常运营 核心活动（见下文技术支助）。 由PI组成的指导委员会负责监督中心核心， 代表参与本提案的各部门的高级教师和核心顾问 (ex当然）。Surmeier博士（PI）一直是2P成像核心创建的推动力，

The administration of the Center Core will be distributed into three parts: Administrative Core, Imaging Cores, and a Steering Committee. The Administrative Core will be managed by a Core Advisor who will be assisted by an administrative staff (see Chart on next page). The Core Advisor (22% effort) will be in charge of equipment purchases and negotiating prices with vendors (especially where multiple purchases may enable price reductions), managing the administrative staff, maintaining an inventory of core equipment and supplies, scheduling regular meetings of the Steering Committee, and serving as liaison between the Steering Committee and the Core Directors. He will also be responsible for overseeing the system improvement projects, coordinating activities with our corporate partner and consultants, and organizing and completing the annual reports to NIH. Dr. Hockberger, Director of the 2P Imaging Cores in Physiology and consultant on the 2P cores in Pediatrics and Neurology, has agreed to serve as the Core Advisor. He has been active in the field of optical physiology for 25 years, and he has made seminal contributions related to dendritic Ca2+ signaling, the role of differential adhesion in neuronal migration and pathfinding, and the sources and remedies of phototoxicity during live cell microscopy. He has been responsible for developing imaging resources (including CCD-based and 2P imaging) at NU, Loyola University (Chicago), University of Erlangen (Germany), and the University of Bonn (Germany). He has been an active participant in the International Society for Optical Engineers (SPIE) for the past 12 yrs, and he has been an invited speaker at numerous national and international symposia. At NU, he has taken a leading role in the education of graduate students and postdocs on the quantitative aspects of biological imaging. Since 1992, he has directed a graduate course (IGP 415: Biological Imaging: Principles and Applications) that teaches the theory and practice of quantitative image analysis in the life sciences. Each imaging core will be managed by a Core Director. We have identified appropriate faculty who have agreed to serve as Core Directors (see Chart), and their effort (5%) will be contributed by their respective departments. Directors will be responsible for oversight of the core, advising users on policies within the core, and keeping track of core usage. Each Director will have technical support to assist in running the day to day activities of the core (see Technical support, below). Oversight of the Center Core will be the responsibility of a Steering Committee comprised of the PI, senior faculty representing the various departments involved in this proposal, and the Core Advisor (ex officio). Dr. Surmeier (PI) has been the driving force behind the creation of the 2P imaging cores in