2008 Cell Death Gordon Research Conference

描述（由申请人提供）：细胞死亡有助于许多不同的过程，包括（但不限于）正常胚胎发育期间细胞的消除，免疫系统的成熟和功能，以及放射或化疗治疗后细胞的移除。因此，适当时间的细胞死亡失败可能导致发育异常、免疫缺陷和癌症治疗失败。过度的细胞死亡是许多退行性和年龄相关疾病的病理基础，而在许多情况下，适当计划程序的失败有助于致癌。因此，我们希望对细胞死亡过程（包括细胞凋亡、坏死和自噬）的详细了解将大大提高我们治疗包括神经退行性疾病和癌症在内的各种病理状况的能力。2008年戈登细胞研究会议将促进尚未发表的最新科学信息的自由交流，重点关注细胞死亡的主要不同类型的机制。这次会议既应加速该领域的发现，又应有助于确定治疗干预因细胞死亡调节不当而导致的许多疾病的新方法。人体含有不同寿命的细胞。例如，白细胞和皮肤细胞被设定为快速死亡并被新细胞所取代。另一些细胞，比如大脑中的神经细胞，被编程为在个体的一生中存活下来，很少被替换。然而，过多的细胞死亡会导致过早的脑细胞死亡，而过少的细胞死亡会导致癌症中的细胞积累。2008年戈登细胞研究会议将促进尚未发表的最新科学信息的自由交流，重点关注细胞死亡的主要不同类型的机制。这次会议既应加速该领域的发现，又应有助于确定治疗干预因细胞死亡调节不当而导致的许多疾病的新方法。

DESCRIPTION (provided by applicant): Cell death contributes to many different processes, including (but not restricted to) the elimination of cells during normal embryo development, the maturation and functioning of the immune system, and the removal of cells after treatment with radiation or chemotherapeutics. Hence, a failure of appropriately timed cell death can lead to developmental abnormalities, immune deficiencies, and a failure of cancer therapy. Excessive cell death underlies the pathology of many degenerative and age-related disorders, while a failure of appropriately scheduled programs contributes in many instances to carcinogenesis. Therefore, we are hopeful that a detailed understanding of the cell death processes (including apoptosis, necrosis, and autophagy) will greatly enhance our ability to treat a wide range of pathological conditions, including neurodegenerative disorders and cancer. The 2008 Gordon Research Conference on Cell will promote free exchange of state-of-the-art unpublished scientific information, focusing on the mechanisms that specify the main distinct types of cell death. The conference should both accelerate discovery in the area and help to identify new approaches to for therapeutic intervention in the many diseases that result from inappropriate regulation of cell death. The human body contains cells with different life expectancies. For example, white blood cells and skin cells are programmed to rapidly die and be replaced by new cells. Others, such as nerve cells in the brain are programmed to survive the lifetime of the individual and are seldom replaced. However, too much cell death can result in untimely brain cell death, while too little cell death contributes to the cell accumulation seen in cancer. The 2008 Gordon Research Conference on Cell will promote free exchange of state-of-the-art unpublished scientific information, focusing on the mechanisms that specify the main distinct types of cell death. The conference should both accelerate discovery in the area and help to identify new approaches to for therapeutic intervention in the many diseases that result from inappropriate regulation of cell death.