CHROMATIN STRUCTURE AND DNA REPAIR

描述(申请人提供)：染色质结构和DNA修复在基因组稳定性中起着关键作用，而基因组稳定性是正常细胞功能所必需的。因此，DNA修复机制在基因组不稳定性的研究中占有重要地位。基因组的不稳定性也与疾病的发病机制有关，例如癌症的发展和衰老。通过基因组不稳定性与癌症进化有机械联系的基本过程包括染色质的作用。这些专门过程中的最新发现不仅为诊断和预后策略提供了概念框架，还为新的DNA修复和染色质修饰驱动疗法提供了概念框架。创新、创造性和经过科学检验的想法的聚集及其在私人会议环境中的传播，预计将促进领先领域研究人员之间有意义的相互交谈，目的是解开基于机制的抗击癌症的战略，并确定现实的未来方向。此外，互动预计将为当地科研企业提供亟需的动力，该企业在最近遭遇了一些不幸的挫折。这次研讨会的一个更重要的目的是激发和培养年轻学生和博士后的创造性思维，他们将承担起维持和推进癌症研究领域的责任。这些研讨会的目标是汇聚美利坚合众国各机构的老牌和正在发展中的科学家以及国际研究人员，通过在圣路易斯举行的为期两天的会议上在多个会议上介绍他们的科学发现，参与高度互动的科学讨论。会议的主要目的是传播与该主题相关的基础、临床和转译研究的当前知识状况，并促进与会者之间的关键合作。会议的主题是染色质结构和DNA修复，将涵盖(1)染色质结构和DNA损伤检测，(2)染色质结构和DNA修复机制，(3)染色质结构和基因组稳定性等领域的最新领域。该研讨会是为了纪念已故的L.Tolmach博士对癌症生物学领域的开创性贡献而设立的。

DESCRIPTION (provided by applicant): Chromatin structure and DNA repair play a critical role in genomic stability, which is essential for normal cellular function. Mechanisms of DNA repair therefore are prominently featured in the studies of genomic instability. Genomic instability is also related to disease pathogenesis, e.g., cancer development and ageing. Fundamental processes mechanistically linked to the evolution of cancer through genomic instability include the role of chromatin. The latest discoveries in these specialized processes provide conceptual framework for not only diagnostic and prognostic strategies but novel DNA repair and chromatin modifying driven therapeutics. A congregation of innovative, creative and scientifically tested ideas and their dissemination in an intimate meeting setting is expected to foster meaningful cross-talk amongst leading area researchers for the purpose of unraveling mechanism-based strategies for combating cancer and establishing realistic future directions. In addition, interactions are expected to provide a much-needed impetus to the local scientific research enterprise that has suffered some unfortunate set backs in the recent past. A more important purpose served by this Symposium will be inspiring and cultivating creative thoughts in fertile minds of young students and post-doctoral fellows upon whom will lie the responsibility for sustaining and advancing the field of cancer research. The goal of these Symposia is to bring together established and developing scientists from various institutions within United States of America as well as international investigators to participate in highly interactive scientific discourses through the presentation of their scientific findings in multiple sessions over a two-day meeting in St Louis. The primary purpose of the meeting is to disseminate the current state of knowledge in basic, clinical and translational research related to the topic and foster critical collaborations between the participants. The theme of the meeting will be Chromatin Structure and DNA Repair which will cover the latest areas in the fields of (1) Chromatin structure and DNA damage sensing, (2) Chromatin structure and DNA Repair Mechanisms and (3) Chromatin structure and Genome Stability. The symposium was established to commemorate the seminal contributions of late Dr. L. Tolmach to the field of Cancer Biology.