ALVEOLAR MACROPHAGE PROTEOMICS IN HIV-ASSOCIATED EMPHYSEMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 HIV抗体阳性的吸烟者容易患上肺气肿。为了更好地了解HIV-肺气肿，目前的提议试图解决两个具体目标：具体目标1.描绘HAART时代与HIV相关的肺气肿的自然历史和相关的生理机制。在这个目标中，我们将重新检查一组HIV血清阳性的受试者，这些受试者在大约10年前曾进行过详细的肺功能评估和计算机断层扫描。具体目的2.在这个目的中，我们将比较HIV血清阳性吸烟者和无肺气肿HIV血清阳性吸烟者肺泡巨噬细胞的蛋白质组。这个项目的成功完成将使我们能够更好地描述在艾滋病毒血清阳性人群中发生的与吸烟有关的肺损伤的重要性。此外，这项提议中提出的研究将提供一个独特的机会来描绘早期肺气肿进展的相关机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV-seropositive smokers are predisposed to develop pulmonary emphysema. In order to gain better insight into HIV-emphysema the current proposal seeks to address two specific aims: Specific Aim 1. To delineate the natural history and relevant physiologic mechanisms relevant to HIV-associated emphysema in the HAART era. In this aim we will re-examine a cohort of HIV-seropositive subjects who have had detailed assessment of lung function and computed tomography ~10 years earlier. Specific Aim 2. In this aim we will compare the proteomes of alveolar macrophages obtained from HIV-seropositive smokers who are developing emphysema with HIV-seropositive smokers without emphysema. Successful completion of this project will enable us to better delineate the importance of smoking related lung damage occurring in the HIV-seropositive population. Furthermore, the research proposed in this proposal will provide a unique opportunity to delineate relevant mechanisms underlying the progression of early emphysema.