ALVEOLAR MACROPHAGE PROTEOMICS IN HIV-ASSOCIATED EMPHYSEMA

HIV 相关肺气肿中的肺泡巨噬细胞蛋白质组学

• 批准号: 7625468
• 负责人: PHILIP DIAZ
• 金额: $ 30.92万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625468
• 关键词: Address; Alveolar Macrophages; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Highly Active Antiretroviral Therapy; Institution; Lung; Natural History; Physiological; Population; Proteome; Proteomics; Pulmonary Emphysema; Research; Research Personnel; Resources; Respiratory physiology; Smoker; Smoking; Source; United States National Institutes of Health; X-Ray Computed Tomography; cohort; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV-seropositive smokers are predisposed to develop pulmonary emphysema. In order to gain better insight into HIV-emphysema the current proposal seeks to address two specific aims: Specific Aim 1. To delineate the natural history and relevant physiologic mechanisms relevant to HIV-associated emphysema in the HAART era. In this aim we will re-examine a cohort of HIV-seropositive subjects who have had detailed assessment of lung function and computed tomography ~10 years earlier. Specific Aim 2. In this aim we will compare the proteomes of alveolar macrophages obtained from HIV-seropositive smokers who are developing emphysema with HIV-seropositive smokers without emphysema. Successful completion of this project will enable us to better delineate the importance of smoking related lung damage occurring in the HIV-seropositive population. Furthermore, the research proposed in this proposal will provide a unique opportunity to delineate relevant mechanisms underlying the progression of early emphysema.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病毒血清反应阳性的吸烟者易患肺气肿。 为了更好地了解艾滋病毒-肺气肿，目前的建议旨在解决两个具体目标：具体目标1。 描述HAART时代HIV相关肺气肿的自然病程和相关生理机制。 在这个目标中，我们将重新检查一组HIV血清阳性受试者，他们在10年前进行了肺功能和计算机断层扫描的详细评估。 具体目标2。 在这个目标中，我们将比较从正在发展肺气肿的HIV血清阳性吸烟者和没有肺气肿的HIV血清阳性吸烟者获得的肺泡巨噬细胞的蛋白质组。 该项目的成功完成将使我们能够更好地描述艾滋病毒血清阳性人群中吸烟相关肺损伤的重要性。 此外，本提案中提出的研究将提供一个独特的机会来描述早期肺气肿进展的相关机制。