LUNG VOLUME REDUCTION SURGERY FOR EMPHYSEMA

最近的证据表明，肺减容手术（LVRS）可能是终末期肺气肿患者的一种有用的治疗选择。初步研究表明，LVRS可改善肺弹性回缩和呼吸肌功能，从而改善严重肺气肿患者的气流和运动耐量。 在某些人中，这已经转化为生活质量的大幅改善。 然而，关于手术仍存在许多问题，包括肺功能的改善是否持久，以及手术的风险/受益究竟是什么。 此外，关于适当的筛查测试和应选择进行这种类型手术的理想患者，仍然存在许多问题。 为了解决这些问题，NIH和卫生保健融资管理局资助了一项多中心研究。 俄亥俄州州立大学医学中心被选为参与这项随机临床试验的18个中心之一。

Recent evidence has suggested that lung volume reduction surgery (LVRS) may be a useful therapeutic option for pateints with end stage emphysema. Preliminary data has suggested the LVRS may improve lung elastic recoil as well as respiratory muscle function thereby improvong air flow and exercise tolerance in patients with severe emphysema. In certain individuals this has translated into substantially improved quality of life. However numerous questions remain regarding the surgery including whether or not the improvement in lung function is longlasting and what precisely are the risks/benefits of the procedure. Furthermore, numerous questions remain regarding the appropriate screening tests and the ideal patients that should be selected for this type of surgery. In order to address these questioins, a multi-center study has been funded by the NIH and the Health Care Financing Administration. The Ohio State University Medical Center has abeen selected as one of 18 centers participating in this randomized clinical trial.