Plasmodium Genome Database

描述（由申请人提供）：疟原虫基因组数据库<http://PlasmoDB.org>建立于2000年，以加快疟疾研究界对基因组规模数据集的访问，从恶性疟原虫的参考基因组序列开始。PlasmoDB整合了来自恶性疟原虫基因组计划的完成和未完成序列、遗传和光学图谱数据、测序中心提供的完成序列的策划注释、使用多种算法对DNA和预测基因/蛋白质序列的自动分析、与GenBank/EMBL和其他数据库的比较、来自不同物种的未完成基因组序列和疟原虫EST以及来自SAGE和微阵列计划的表达数据。所有信息都被纳入一个全面的关系数据库，方便用户查询。联机数据库每天收到来自100多个国家用户的多达13 000次点击，并在全世界分发了数千份光盘。PlasmoDB最初通过Burroughs Wellcome基金的种子基金获得支持;该应用程序寻求资金来维护和扩展数据库，以造福整个研究社区。数据库增强是一个正在进行的研究和开发项目，产生了广泛适用于任何生物体的基因组规模数据集的工具。具体目标是： 1.加强对PlasmoDB作为社区资源的访问，包括为关系查询开发改进的Web界面。 2.提供社区输入和响应的机制，包括实现评论表单（用于网站，基因注释和其他数据类型），跟踪对评论的响应，并在PlasmoDB上发布评论和响应。 3.扩大可用数据的深度和范围，包括表达谱和蛋白质组学数据等。 4.提供疟原虫物种的比较分析，促进基因和调控元件的鉴定、遗传图谱绘制、进化研究等。 该项目的总体目标是开发和维持一个数据库，以加快生物发现，包括确定用于防治疟疾的药物靶标和疫苗抗原。

DESCRIPTION (provided by applicant): The Plasmodium Genome Database <http://PlasmoDB.org> was established in 2000, to expedite access of the malaria research community to genomic-scale datasets, beginning with the reference genome sequence for P. falciparum. PlasmoDB incorporates finished and unfinished sequence from the P. falciparum genome project, genetic & optical mapping data, curated annotation of finished sequences provided by the sequencing centers, automated analyses of DNA and predicted genes/protein sequences using multiple algorithms, comparisons with GenBank/EMBL and other databases, unfinished genomic sequences and Plasmodium ESTs from various species, and expression data from SAGE and microarray projects. All information is incorporated into a comprehensive relational database, facilitating user queries. The on-line database receives up to 13,000 hits per day, from users in more than 100 countries, and many thousands of CD-based copies have been distributed worldwide. PlasmoDB was initially supported through a seed grant from the Burroughs Wellcome Fund; this application seeks funding to maintain and extend the database, for the benefit of the research community at large. Database enhancement is an ongoing research and development project, resulting in tools that are broadly applicable to genomic-scale datasets for any organism. Specific aims seek to: 1. Enhance access to PlasmoDB as a community resource, including development of an improved web interface for relational queries. 2. Provide a mechanism for community input and response, including implementation of comment forms (for the web site, gene annotation, and other data types), tracking responses to comments, and posting comments and responses at PlasmoDB. 3. Expand the depth and scope of data available, including expression profiling and proteomics data, etc. 4. Provide comparative analyses of Plasmodium species, facilitating identification of genes and regulatory elements, genetic mapping, evolutionary studies, etc. The overall goal of this project is to develop and maintain a database that expedites biological discovery, including the identification of drug targets and vaccine antigens useful in the fight against malaria.