Transplant Surgery Scientist Training Program

描述（由申请人提供）： 美国移植手术的空前增长要求新一代的医学博士/博士研究人员应接受与移植相关的基础和临床/转化科学方面的培训。本申请建议开发一个培训计划，结合了优秀教师的指导与综合教学和研究计划。为了实现这些目标，我们着重于以下目标：1）为受训者提供津贴支持; 2）由高级研究人员提供指导; 3）保护受训者免受争夺其时间的临床活动的影响; 4）维持一个扩大候选人库的种族多样性和质量的行政结构; 5）为基础和临床科学学员提供成功进行移植相关研究所需学科的严格课堂学习基础;以及6）继续进行持续的评估过程，以确定该计划是否符合其目标和目的。一名博士预科生和两名博士后博士学员将于首两年接受训练。然而，在该计划的成功预期，职位的数量将在第3年通过5年扩大到2个博士前和3个博士后实习生/年。该提案的一个主要目标是吸引来自大学和医学院许多不同学科的受训人员从事与移植有关的研究。因此，目前导师名单的范围涵盖了从移植生物学基础科学到病人护理的所有主题。一组优秀的导师将为学员提供与移植相关的基础科学和临床研究轨道的机会。基础科学轨道将利用导师在医学院沿着与教师在生物医学工程，材料科学和化学实验室已经参与移植手术的研究。临床研究学员将从移植手术的三个国家多中心研究（A2 ALL，CTOT和CITR）的数据库中提取。候选人将受益于博士前几年的学费支付，以及入学并成功完成大学公共卫生硕士或临床研究硕士学位课程所需的费用。该计划的启动正值西北大学范伯格医学院的大幅增长，从而使其成为移植手术科学研究的T32 NRSA奖的理想场所。

DESCRIPTION (provided by applicant): The unprecedented growth in transplant surgery in the United States requires that a new generation of M.D./Ph.D. investigators be trained in transplant-related basic and clinical/translational sciences. This application proposes to develop a training program that combines mentorship from an outstanding faculty with an integrated didactic and research program. To achieve these objectives, we focused on the following goals: 1) to provide stipend support for trainees; 2) to provide mentorship by senior investigators; 3) to protect trainees from clinical activities that compete for their time; 4) to sustain an administrative structure that expands the ethnic diversity and quality of the candidate pool; 5) to provide both basic and clinical science trainees a rigorous base of classroom study in the disciplines necessary for successfully conducting transplant-related research; and 6) to continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives. One pre-doctoral and two post-doctoral M.D./Ph.D. trainees will be enrolled in the first two years. However, in expectation of the program's success, the number of positions will be expanded during years 3 through 5 to 2 pre-doctoral and 3 postdoctoral trainees/year. A major objective of the proposal is to attract trainees to transplant-related research from a number of diverse disciplines within the University and medical school. Thus, the scope of the current list of mentors runs the gamut of topics from the basic science of transplant biology to patient care. An outstanding group of mentors will provide trainees opportunities in transplant-related basic science and clinical research tracks. The basic science track will take advantage of mentors within the medical school along with faculty in biomedical engineering, materials science, and chemistry laboratories already involved in transplant surgery research. Clinical research trainees will draw from databases of three national multicenter research studies in transplant surgery (A2ALL, CTOT, and CITR). Candidates will benefit from tuition payment during pre-doctoral years and fees required to enroll and successfully complete the University's Master of Public Health or Master of Science in Clinical Investigation degree programs. The initiation of the program comes at a time of substantial growth in the Northwestern University Feinberg School of Medicine, thus making this an ideal site for this T32 NRSA award for research in transplant surgery sciences.