Training Grant in Dynamic Aspects of Chemical Biology

描述（由申请人提供）：本申请要求继续支持堪萨斯大学化学系、药物化学系和分子生物科学系化学生物学动态方面的博士培训项目。本专业旨在培养具有生物信息工作水平和技能的化学类博士研究生和具有化学信息工作水平和技能的生物类博士研究生。堪萨斯大学的这个项目利用了当地50多年来科学家在化学、生物学和制药科学领域密切有效合作的传统。导师将从参与的院系中抽取：化学系11.5名教师，分子生物科学系6.5名教师，药物化学系6名教师，药理学和毒理学系1名教师（0.5名教师同时担任药物化学和化学）。要求支助七名受训人员，比上次提出的申请增加一名。学员完成一个项目，其特点是在一个既定的实力领域集中博士教育和研究；将受训者的知识和技能扩展到超出部门界限的领域的一系列课程；研究轮转，让学员在项目的所有领域都有个人研究经验；参加特别研讨会和年度专题讨论会的组织和发言。博士生的博士研究项目主要集中在以下三个方面：(1)生物相关分子的合成；(2)生物物理结构分析；(3)酶机制与生物分子动力学。培训资助课程从生物信息学和/或分子建模的核心课程开始，以及科学诚信问题课程。然后每个化学和药物化学的学生都必须选修至少一门分子生物科学的课程，反之亦然。此外，学员满足其所在部门的所有博士要求。所有受训者进行两次研究轮转。学员管理和参与年度培训补助金研讨会，并邀请演讲者参加化学生物学研讨会。

DESCRIPTION (provided by applicant): This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, and Molecular Biosciences at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 11.5 faculty members from Chemistry, 6.5 from Molecular Biosciences, 6 from Medicinal Chemistry, and 1 from Pharmacology and Toxicology (the 0.5 reflects a faculty member with joint appointments in Medicinal Chemistry and Chemistry). Support is requested for seven trainees, an increase of one from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength; a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries; research rotations that give trainees personal research experience in all areas of the program; and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into one of three areas: (1) synthesis of molecules of biological relevance; (2) biophysical structure analysis; (3) enzyme mechanisms and biomolecular dynamics. The training-grant curriculum begins with core courses in bioinformatics and/or molecular modeling, along with a course, Issues in Scientific Integrity. Then each chemistry and medicinal chemistry student is required to take at least one elective course in molecular biosciences and vice versa. In addition, trainees meet all doctoral requirements of their home departments. All trainees carry out two research rotations. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar.