Training in Translational Breast Cancer Research

描述(申请人提供)：乳腺癌是女性中最常见的癌症，占美国癌症诊断的三分之一。根除乳腺癌可能需要不同科学学科的合作，并需要培训新一代的基础和转化型研究人员。这项培训基金的目标是培训6名博士后研究员(包括医学博士和博士研究生)，在荷尔蒙调节、信号转导、细胞周期控制、细胞结构和运动以及应用于乳腺癌的实验疗法方面进行最先进的研究。拟议拨款的优势是培训教师。来自基础科学系和临床科室(包括布拉曼家族乳腺癌研究所和西尔维斯特综合癌症中心)的13名教员是一个优秀的团队，他们的研究资金充足，涵盖了乳腺癌研究的结构、分子和细胞生物学、基础和翻译科学方法。教职员工在培养研究生和博士后研究员(包括医学博士/博士)方面拥有丰富的经验，他们已经成为成功的独立研究人员。该计划的总体目标是为受训者提供指导，以获得独特的研究技能，并塑造他们的智力严谨性，以维持在乳腺癌方面独立的、临床上知情的研究生涯。所有受训人员都必须参加正式的授课课程、座谈会、乳腺癌研究研讨会、大型研讨会、研讨会、期刊俱乐部和年度静修活动，这些活动为不同学科之间的思想交流和互动提供了论坛。受训者的研究进展将在每两周一次的数据审查中得到密切监测。因此，这一培训计划满足了全国对乳腺癌研究人员的严重需求，这些研究人员在基础、临床和翻译研究方面拥有丰富的知识。拟议的计划具有许多独特的优势，包括：1)存在一个专门的乳腺癌研究所(布拉曼家族乳腺癌研究所)和一个著名的癌症中心(西尔维斯特综合癌症中心)，2)总体上和计划主任的研究生产力、研究资金、培训经验、管理能力和经验，以及3)促进乳腺癌临床和基础研究之间持续互动的机会和可用的基础设施。

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among women, accounting for one third of cancer diagnosis in the United States. Eradication of breast cancer is likely to require a partnership of diverse scientific disciplines and training of new breed of basic and translational researchers. The goal of this training grant is to train 6 postdoctoral fellows (including MD and PhD) to perform state-of-the-art research in hormonal regulation, signal transduction, cell cycle controls, cell structure and motility, and experimental therapeutics applied to breast cancer. The strength of the proposed grant is the training faculty. Drawn from both basic science departments and clinical departments (including Braman Family Breast Cancer Institute and Sylvester Comprehensive Cancer Center), the 13 faculty members are an excellent group whose well-funded research comprises a cross-section of structural, molecular and cell biological, basic and translational science approaches to breast cancer research. The faculty members have extensive experience in training graduate students and postdoctoral fellows (including MD/PhD) who have gone onto become successful independent researchers. The overall goal of this program is to provide guidance for trainees to acquire unique research skills and to mold their intellectual rigor to sustain an independent, clinically-informed research career in breast cancer. All trainees are required to attend formal didactic courses, symposia, breast cancer research seminars, grand rounds, workshops, journal clubs and an annual retreat, which provide forum for exchange of ideas and interaction among different disciplines. Progress of the trainee's research will be closely monitored in bi-weekly data reviews. Thus this training program fulfills a serious national need for breast cancer researchers with ample knowledge in basic, clinical and translational research. The proposed program has many unique strengths including : 1) the existence of a specialized breast cancer research institute (Braman Family Breast Cancer Institute) and a well-known cancer center (Sylvester Comprehensive Cancer Center), 2) the research productivity, research funding, training experience, and administrative capability and experience of program faculty in general and the program directors in particular, and 3) the opportunity and availability of infrastructure for fostering continued interactions between clinical and basic research in breast cancer.