UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

描述(由申请者提供)：我们申请资金，在华盛顿大学及其附属机构建立一个跨学科的培训计划，涉及血红蛋白疾病、基因组学和蛋白质组学。该项目的重点是为研究生的研究生涯做准备，这些研究包括血红蛋白疾病、基因组学、蛋白质组学和计算生物学的知识。除了他们在血红蛋白疾病方面的研究培训外，学员还将参与一些项目，包括发现基因组如何编码基因产品执行复杂生物学任务的信息；测量和分析序列变异；开发适应高通量实验分析的技术，以及生成新的计算工具来分析基因组和蛋白质组数据。鉴于我们的学员在教育背景和职业目标方面的预期差异很大，该项目强调高度个性化的培训和跨学科研究。一个多学科的教职员工小组将作为受训者的导师，他们参与了血红蛋白病、基因组学和蛋白质研究，并因他们的培训记录而被选中。在血红蛋白疾病领域有杰出贡献的资深科学家将担任受训人员的顾问，他们将在最初6个月的实验室轮换期间为受训人员提供建议，以选择他们的课程工作和他们的研究导师。他们还将在整个培训期间向受训者提供建议，目标是继续把重点放在基因组学和蛋白质组学工具的应用上，以回答血红蛋白疾病领域的重要问题。研究经验将与各种教学课程和选修课相辅相成。关于道德研究行为的培训是该计划的一部分。知识的广度和计划的凝聚力是通过学员参加两个以基因组研究和计算生物学为特色的系列研讨会、期刊俱乐部、进行中的研究以及由计划教师领导的各种主题讨论小组来实现的。培训预计将持续4至5年，其中前三年将由培训计划提供支持，其余的将由受训者的研究导师或KO8的研究基金提供支持。

DESCRIPTION (provided by applicant): We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomics and proteomics at the University of Washington and affiliated institutions. The program focuses on preparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and computational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developing technologies to accommodate high throughput experimental assays, and generating new computational tools to analyze genomic and proteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A multidisciplinary group of faculty, selected for their involvement in hemoglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record of contributions in the field of hemoglobinopathies will serve as advisors of the trainees They will advise the trainees in the initial 6 month period of laboratory rotations, in selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keeping their focus on application of the genomics and proteomics tools in answering important questions in the field of hemoglobinopathies. Research experience will be complemented with a variety of didactic courses and electives. Training on ethical research conduct is part of the program. Breadth of knowledge and program cohesion are achieved through trainee participation in two seminar series that feature genomic research and computational biology, journal clubs, research in progress, and a variety of topical discussion groups led by program faculty. Training is expected to last 4 to 5 years of which the first three will be supported by the training program and the remaining by research funds of research mentors or KO8s of the trainees.