A VOC Dosimeter Based On A Colorimetric Sensor Array

我们发明了一种非常简单，但非常强大的新技术， 挥发性有机化合物（VOCs）的识别：比色传感器阵列。它们很便宜， 基于分析物与金属卟啉和其它的平衡相互作用的一次性传感器阵列 化学反应染料。与人类嗅觉一样，我们的比色传感器阵列使用大量的 交叉反应传感器，探测广泛的化学性质。通过数字化监控 通过阵列中每种染料的颜色，我们可以定量测量对挥发性有机物的复合响应。 化学计量学模式识别是非常强大的与这些阵列，因为他们非常高 维度 我们现在正在将这项工作扩展到生物医学应用，具体目标集中在 研制个人化学剂量计，用于检测、识别和定量 环境/工作场所VOC。我们的阵列的灵敏度允许快速检测非常低水平的 最易挥发的毒物这是一种转化技术，应该在工作场所找到大量的使用 监测化学品暴露。 我们在这些领域的努力应该导致（1）分子传感器开发的根本性进展 这种传感器阵列的识别和生物医学应用，（2）开发和改进 挥发性化学毒物的快速和连续鉴定和定量技术，以及 最重要的是，（3）一个非常便携的设备的原型，用于评估个人VOC 暴露;该设备将提供连续、定量、可靠、可再现、多路复用的测量 快速反应的环境暴露（即，秒），基本上不需要用户干预 用于现场部署和数据采集。这种独立的，易于使用的设备将被证明是理想的多- 未来使用的接触点接触优先环境化学品的分析物测量 对不同人群进行基于人群的生物医学研究。我们的设备将能够测量分析物 集中，将基本上不需要用户干预外地部署和数据 捕获，并将能够实时遥测到一个集中的系统。

We have invented a very simple, but extremely powerful, new technology for detection and identification of volatile organic compounds (VOCs): colorimetric sensor arrays. These are inexpensive, disposable sensor arrays based on equilibrium interactions of analytes with metalloporphyrins and other chemically responsive dyes. As with human olfaction, our colorimetric sensor arrays use a large number of cross-reactive sensors that probe a wide range of chemical properties. By digitally monitoring the change in color of each dye in the array, we have a quantitative measure of a composite response to volatile organics. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality. We are now extending this work to biomedical applications, with specific aims focusing on the development of a personal chemical dosimeter for the detection, identification, and quantification of environmental/workplace VOCs. The sensitivity of our arrays permits rapid detection of very low levels of most volatile toxicants. This is a translational technology that should find substantial use in workplace monitoring of chemical exposure. Our efforts in these areas should lead (1) to fundamental advances in sensor development for molecular recognition and biomedical applications of such sensor arrays, (2) development and refinement of technology for the rapid and continuous identification and quantitation of volatile chemical toxicants, and most importantly, (3) prototyping of an extremely portable device for the assessment of personal VOC exposure; this device will provide continuous, quantitative, reliable, reproducible, multiplexed measurement of environmental exposures with rapid response (i.e., seconds) that requires essentially no user intervention for field deployment and data capture. This self-contained, easy-to-use device will prove ideal for multi- analyte measurement of point-of-contact exposures to priority environmental chemicals for use within future population-based biomedical studies of diverse populations. Our device will be able to measure analyte concentrations continuously, will require essentially no user intervention for field deployment and data capture, and will be capable of real-time telemetry to a centralized system.