SEARCH for Diabetes in Youth 2: Ohio Center

这项建议建立在一个为期五年的研究项目，青年糖尿病，其标准化数据 收集工作，经验丰富的调查员团队，建立了病例确定基础设施， 多样的人口基础。这是一个来自六个临床试验机构的通用集成应用程序， 建议继续并扩大联合国难民事务高级专员办事处开展的工作，以解决以下具体问题： 研究目的：目的1：确定2006-2009年新发病例年龄小于 20年，以估计青年糖尿病发病率的时间趋势;目的2：进行纵向 * 对2002-2005年已被征聘到联合国调查科的事件案件采取后续行动，以记录 根据临床和生化因素新诊断的糖尿病;目的3：完整的分析开始在 第一个五年的评估，并扩大护理质量评估的范围，以更广泛地包括 定义的概念和质量度量;目标4：开发和验证简单和低成本的案例定义 和青年糖尿病类型的分类，可用于公共卫生监测。这件事的新奇之处在于 建议包括它的综合性质，汇集了儿童糖尿病的主要和及时的方面 研究：一项流行病学研究，在美国是独一无二的，研究了糖尿病发病率的时间趋势， 青年;解决青年DM自然史的病理生理学组成部分; 护理和生活质量;以及对青年糖尿病病例分类的公共卫生观点。本研究是 这对公众健康至关重要，因为它将提供有关DM是否和多少的信息。 在美国不同种族/民族的青年中，DM如何影响 身体健康，包括并发症，以及有关护理质量和医疗质量的宝贵数据。 这些年轻人的生活。俄亥俄州工厂的主要优势是辛辛那提的主导市场地位 儿童医院医疗中心（CCHMC），CCHMC致力于研究和糖尿病护理， CCHMC与周围社区的良好关系，以及俄亥俄州的良好记录 研究人员成功合作。基于这些优势，俄亥俄州工厂采用了全面的 糖尿病患者数据库，并建立了社区网络，以确定99.8%（估计由 捕获-再捕获分析）的情况下，糖尿病的青年在俄亥俄州的地理区域在搜索1。

This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth. The major stengths of the Ohio site are the dominant market postion of Cincinnati Childen's Hospital Medical Center (CCHMC), CCHMC's commitment to research and diabetes care, the excellent rapport CCHMC has with the surrounding community, and the track record of Ohio SEARCH investigators for successful collaboration. Based on these strengths, the Ohio site used a comprehensive diabetes patient database at CCHMC and built a community network to ascertain 99.8% (estimate by capture-recapture analysis) of the cases of diabetes in youth in the Ohio geographic area in SEARCH1.