SEARCH for Diabetes in Youth 2: California Center

加州中心的这项提案建立在一项为期五年的研究项目--在美国寻找糖尿病 青年，其标准化的数据收集工作，经验丰富的调查团队，建立了案件查明 基础设施和种族多元化的人口基础。这是一个常见的集成应用程序，来自六个 搜索临床中心，建议按顺序继续和扩展搜索所执行的工作 解决以下具体研究目标：目标1：前瞻性地确定新诊断(2006年- 2009年)年龄不到20岁的事件病例，以估计糖尿病发病率的时间趋势 青年中的糖尿病；目标2：对已招募用于搜索的事件病例进行纵向跟踪 2002-2005年，以记录新诊断的糖尿病的演变，根据临床和 生化因素；目标3：完成搜索前五年开始的分析，并扩大 护理质量评估的范围包括更广泛定义的质量概念和衡量标准； 目标4：制定和验证糖尿病类型的简单和低成本病例定义和分类 可用于公共卫生监测的青年。这一建议的新颖性包括其全面的 汇集儿童糖尿病研究的主要和及时方面的自然：流行病学研究， 在美国独一无二的青年糖尿病发病率的时间趋势；病理生理学 关于青少年糖尿病自然病史的组成部分；护理过程和质量的研究 以及从公共卫生的角度对青年糖尿病病例分类进行研究。 加州中心的优势在于其庞大的、多样化的人口；大多数患有糖尿病的年轻人都能得到 该区域8名儿科内分泌科医生中的1名提供医疗保健；以及提供大量 电子健康数据。在770,000多名不到20岁的年轻人中，超过一半是西班牙裔非洲人 美洲人，或亚洲/太平洋岛民，代表南加州。这项研究是至关重要的 对公众健康很重要。它将提供关于糖尿病发病率是否以及多少的信息 美国不同背景的年轻人以及糖尿病如何影响身体健康的人数正在增加， 包括并发症，以及关于糖尿病青年的护理质量和生活质量的数据。

This proposal from the California Center builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical centers, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006- 2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood diabetes research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of diabetes in youth; a pathophysiologic component addressing the natural history of diabetes in youth; a study of processes of care and quality of life; and a public health perspective on case classification of diabetes in youth. The strengths of the California Center are its large, diverse population; that most youth with diabetes receive health care from 1 of the 8 pediatric endocrinologists in the region; and the availability of a vast amount of electronic health data. Of the more than 770,000 youth less than 20 years, over half are Hispanic, African American, or Asian/Pacific Islander,which is representative of southern California. This research is critically important to public health. It will provide information about whether and how much diabetes incidence in the United States is increasing among youth of different backgrounds and how diabetes affects physical health, including complications, as well as data on the quality of care and the quality of life of youth with diabetes.