Gold-Catalysed Cycloisomerisations

环结构在医药、农用化学品、天然产品和精细化学品中普遍存在。因此，环体系的制备和能够控制环化反应是非常重要的，并提出了有机合成的主要挑战。因此，更容易获取这类物种的新方法是非常可取的。更短、更灵活、更容易和更有效的途径可以获得有用的分子，这对更广泛的社区有几个显著的好处。这包括使用更少的试剂、更少的危险化学品和更少的能量来制造重要的分子。所有这些因素在使用我们有限的自然资源（化学和能源）和产生更少的必须处理的危险废物方面都有后续的好处。潜在地，更有效的战略和转换也可以带来经济效益，使整个过程和最终产品的成本更低。因此，开发更有效方法的重要性不能被低估，在这项研究中，我们着眼于使用新的高效催化方法来获取各种碳和杂环结构，这些结构在整个合成化学中都有明确的应用。

Cyclic structures are are ubiquitous in pharmaceuticals, agrochemicals, natural products and fine chemicals. Thus the preparation of ring systems and being able to control cyclisation reactions is very important and presents a major challenge to organic synthesis. New methods to access these type of species more readily are therefore highly desirable. Shorter, more flexible, easy and efficient routes into useful molecules can have several significant benefits to the wider community. This includes the use of fewer reagents, less hazardous chemicals, and less energy to make important molecules. All of these factors have subsequent benefits in terms of using less of our limited natural resources (chemical and energy) and producing less of the dangerous waste materials that must be disposed off. Potentially, more efficient strategies and transformations can also have economic benefits, making overall processes and the resulting products less costly. The importance of developing more effective approaches cannot therefore be understated and in this research we look at using new highly efficient catalytic methods to access a wide variety of carbo and heterocyclic structures that have clear application throughout synthetic chemistry.