Core--Non-Human Primate Facility

非人灵长类核心的目标是提供高度集成的临床管理 以及使用非人类灵长类艾滋病模型进行实验室调查的CFAR调查人员。该核心将加强和便利CFAR调查人员在非人类灵长类动物上进行研究的能力，并促进TNPRC和CFAR在费城的同事之间的科学合作。核心由临床和实验室部分组成。临床部分将获取、安置和照顾非人类灵长类动物，并协助研究人员进行实验设计。中心还将负责动物的日常临床护理和动物程序，如为动物接种疫苗、抽血、收集液体、支气管肺泡灌洗、活组织检查等。核心的实验室部分将进行常规血液学、临床化学、排泄物的卵子和寄生虫检查、微生物学以及所有身体和活组织的病理检查，以支持动物研究。该中心还将提供流式细胞术和免疫学服务、SIV和SIV病毒储存和分离，以及包括原位杂交、免疫组织化学、共聚焦显微镜和图像分析在内的专门病理服务。核心还包括动物和动物对发育研究的支持。我们期望，将非人类灵长类资源和专门研究专门知识与非人类灵长类艾滋病模型相结合，将加强CFAR的艾滋病研究任务，并导致新的更强有力的合作，并吸引新的研究人员使用非人类灵长类艾滋病模型。

The objective of the Non-Human Primate Core is to provide highly integrated clinical management and laboratory investigations using non-human primate models of AIDS to CFAR investigators. The Core will enhance and facilitate the ability of CFAR investigators to perform studies in non-human primates and promote scientific collaborations between the TNPRC and CFAR colleagues in Philadelphia. The Core consists of clinical and laboratory components. The clinical component will acquire, house and care for the non-human primates and assist investigators with experimental design. The Core will also be responsible for the daily clinical care of animals and animal procedures such as immunizing the animals, blood draws, fluid collection, bronchoalveolar lavage, biopsies, etc. The laboratory component of the Core will perform routine hematology, clinical chemistry, ova and parasite examination of feces, microbiology, and pathologic examination of all necropsies and biopsies in support of the animal studies. The Core will also provide flow cytometry and immunology services, SIV and SHIV viral stocks and isolation, and specialized pathology services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. The Core also includes animals and animal support for developmental studies. It is our expectation that the combination of non-human primate resources and specialized research expertise with non-human primate models of AIDS will enhance the AIDS research mission of the CFAR and result in new and stronger collaborations as well as attracting new investigators to use non-human primate models of AIDS.