Alzheimer's Disease Core Center

描述(由申请者提供)：自1990年以来，纽约大学ADCC一直在为一个关于老龄化和AD的综合、多学科研究项目提供核心资源和试点研究支持，该项目涵盖基础研究和心理社会研究。ADCC的主要科学目标是促进和加强有助于早期诊断和预防的研究。在接下来的5年里，核心资源将用于研究从正常衰老到轻度认知障碍(MCI)和早期AD的转变，并检查可能与早期AD重叠的其他痴呆症病因。除了NYUSM，内森·克莱恩研究所(NKI)、纽约基础研究所(IBR)和其他纽约市地区设施的调查人员也参与其中。对AD及相关疾病患者、MCI受试者和认知正常受试者进行纵向解剖研究。在执行委员会和外部科学咨询委员会任职的一名主任和八名协理领导人监督ADCC。支持的标准ADCC核心包括行政、临床、神经病理学、数据管理和教育核心。另外两个重要资源，神经成像和护理核心，显著加强了ADCC调查人员的研究贡献。临床核心包括脑脊液和血液样本库，以及一个专注于少数族裔招募的卫星多元文化诊所。神经病理学核心包括IBR的一个形态测量部分和太阳健康研究所(亚利桑那州太阳城)的一个卫星。每年，ADC直接支持几项试验性研究，并提供核心资源(主题、临床研究和广泛的当前研究)，并得到美国国立卫生研究院和其他来源的主要支持。与其他ADC和国家财团进行了广泛的合作，来自纽约大学ADCC的数据与国家阿尔茨海默氏症协调中心(NACC)和许多合作调查人员共享。纽约大学ADCC已经并将继续为消除AD问题做出实质性贡献。

DESCRIPTION (provided by applicant): Since 1990, the ADCC at NYU has been providing core resources and pilot study support to a comprehensive, multidisciplinary research program on aging and AD that spans basic through psychosocial research. The main scientific goal of the ADCC is to facilitate and enhance research that will lead to early diagnosis and prevention. Over the next 5-years, core resources will be used to study the transition from normal aging to mild cognitive impairment (MCI) and early AD, and also to examine other dementia etiologies that may overlap with early AD. In addition to NYUSM, investigators at the Nathan Kline Institute (NKI), the NYS Institute for Basic Research (IBR), and other New York City area facilities are also participating. Patients with AD and related disorders, subjects with MCI, and cognitively normal subjects are studied longitudinally through postmortem. A Director and eight Associate Leaders who serve on an Executive Committee and an External Scientific Advisory Committee supervise the ADCC. Standard ADCC cores supported consist of Administrative, Clinical, Neuropathology, Data Management and Education Cores. Two additional important resources, Neuroimaging and Caregiver Cores, significantly strengthen the research contributions of the ADCC investigators. The Clinical Core includes CSF and Blood Sample Banks and a Satellite Multicultural Clinic focusing on minority recruitment. The Neuropathology Core includes a morphometry component at IBR and a satellite at the Sun Health Research Institute (Sun City, AZ). Each year, the ADC directly supports several pilot studies, and provides core resources (subjects, clinical to extensive current research receiving primary support from the NIH and other sources. There is extensive collaboration with other ADC's and national consortia, and data from the NYU ADCC is shared with the National Alzheimer's Coordinating Center (NACC) and with numerous collaborating investigators. The NYU ADCC has made and will continue to make substantial contributions toward eliminating the problem of AD.