Sensory Processing Dysfunction in Neuropsychiatric Illness

描述(由申请人提供)：这是根据计划公告PAR-06-357建立综合行为科学的翻译研究R24奖的申请。美国国立卫生研究院近几十年来的长期投入，在情感、动机和认知等领域积累了大量知识。然而，基础行为科学的理论、方法、知识和见解还没有被充分利用来理解诸如精神分裂症等紧迫的公共卫生问题。该项目的总体目标是发展一个合作网络，鼓励系统地将基本行为理论、方法和发现转化为旨在减轻精神疾病行为障碍，特别是精神分裂症负担的研究。核心项目包括一名临床研究人员(贾维特)和两名基础行为科学研究人员(希利亚德，施罗德)之间的合作，将神经认知基础科学的最新进展转化为精神分裂症的研究，并将精神分裂症感觉加工障碍的最新发现转化为改进的基础和翻译模型的开发。感觉障碍是翻译研究的理想模型，因为组成过程很容易被基础行为科学家研究，并转换成动物模型。此外，该领域正在进行的行为研究允许改进现有的测量方法，并允许基础科学家和行为科学家之间的递归互动。精神分裂症患者的感觉处理缺陷会“向上泛化”，导致物体识别、阅读和情绪识别等更全面的过程中出现缺陷。本项目期间的研究将侧重于加强进行翻译研究的能力，包括开发新的范例、合作和基础设施。

DESCRIPTION (provided by applicant): This is an application for an R24 award under program announcement PAR-06-357 Building Translational Research in Integrative Behavioral Science. Long-term investment by NIH over recent decades has resulted in a large body of knowledge in such areas as emotion, motivation, and cognition. However, the theory, methods, knowledge and insights from the basic behavioral sciences have not been fully utilized in understanding pressing public health issues such as schizophrenia. The overall goal of this project is the development of a network of collaborations that will encourage the systematic translations of basic behavioral theory, methods and findings into research designed to reduce the burden of mental illness behavioral disorders, particularly schizophrenia. The core project consists of a collaboration between one clinical researcher (Javitt) and two basic behavioral science researchers (Hillyard, Schroeder) to translate recent advances in the basic science of neurocognition to the study of schizophrenia, and to translate recent findings of sensory processing dysfunction in schizophrenia to the development of improved basic and translational models. Sensory dysfunction represents an ideal model for translational research, in that component processes are readily amenable to study by basic behavioral scientists and for translation to animal models. Further, ongoing behavioral research in the area permits refinement of existing measures and recursive interaction between basic and behavioral scientists. Deficits in sensory processing in schizophrenia "upward generalize" to cause deficits in more holistic processes such as object recognition, reading, and emotion identification. Studies during the present project period will focus on enhancement of capabilities to conduct translational research, including development of new paradigms, collaborations and infrastructure.