Center of Excellence in Environmental Toxicology

描述(由申请人提供) 这是宾夕法尼亚大学建立NIEHS环境健康科学中心的修订申请。该中心的名称为：“环境毒理学卓越研究中心(CEET)”。它将是协调、促进、协同和整合大学内所有与环境有关的卫生研究和外联活动的单一实体。CEET已确定5所学校16个系的50名教职员工为中心成员。这些成员致力于CEET的使命，即：通过基础、翻译和临床研究以及推广，改善生活在工业基础设施老化的城市环境中的公众的健康。研究人员将把环境暴露、分子/细胞效应与健康结果联系起来，设想通过有效的预防或干预战略和/或环境政策的改变，可以在很大程度上消除由环境原因引起的疾病。这项任务将通过四个综合研究核心、三个设施核心和一个充满活力的社区推广和教育方案(COEP)来完成。研究核心由具有国际声誉的调查人员领导。这些核心包括氧化应激和氧化应激损伤(联席董事：Blair和Ischiropoulos博士)、内分泌和生殖中断(联席董事：Strauss和Manson博士)、肺和呼吸道疾病(联席董事：Panettieri博士和Albelda博士)以及基因和环境(联席董事：Rebbeck和Whitehead博士)。这些核心解决了对我们城市地区重要的环境健康问题。不良生殖和妊娠结局、发育障碍以及肺部和呼吸道疾病很常见，并在以器官为基础的核心中得到解决。氧化应激和环境中的基因的核心将阐明环境暴露可导致这些和其他器官系统的毒性的关键机制，从而导致一个完整的中心结构。该设施的核心将是毒物基因组学、毒物蛋白质组学和生物标记物，并将为调查人员提供否则无法获得的服务，并将推动调查人员进入预测毒理学的新时代。COEP将传播研究结果并利用CEET调查人员的专业知识：加强K-16环境健康教育；在宾夕法尼亚州东南部四个面临环境挑战的社区开展社区外联活动，并丰富卫生保健专业人员的教育。COEP已经与社区合作伙伴建立了关系，以进行外联。COEP的目标将是减少有害接触的风险，并改善这些社区内弱势群体的公共健康。

DESCRIPTION (provided by applicant) This is a revised application to establish a NIEHS Center in Environmental Health Sciences at the University of Pennsylvania. The Center will hold the title: "Center for Excellence in Environmental Toxicology (CEET)". It will be the single entity that coordinates, facilitates, synergizes and integrates all environmentally related health research and outreach at the University. The CEET has identified 50 faculty members in 16 Departments from 5 Schools as Center members. These members are dedicated to the CEET mission, which is: to improve the health of the public living in urban environments with an aging industrial infrastructure, through basic, translational and clinical research, and outreach. The investigators will relate environmental exposures, to molecular/cellular effects, to health outcomes, with the vision that diseases with environmental etiology can be largely eliminated by effective prevention or intervention strategies and/or changes in environmental policy. The mission will be accomplished via four integrated Research Cores, three Facility Cores, and a vibrant Community Outreach and Education Program (COEP). The Research Cores are led by investigators with international reputations. These Cores are in Oxidative Stress and Oxidative Stress Injury (co-Directors: Drs. Blair and Ischiropoulos), Endocrine and Reproduction Disruption (co-Directors: Drs. Strauss and Manson), Lung and Airway Disease (co-Directors: Drs. Panettieri and Albelda), and Genes and the Environment (co-Directors: Drs. Rebbeck and Whitehead). These Cores address environmental health issues important to our urban region. Adverse reproductive and pregnancy outcomes, developmental disorders, and diseases of the lung and airway are common, and are addressed in the organ-based Cores. The Cores in Oxidative Stress and Genes in the Environment will elucidate key mechanisms by which environmental exposures can lead to toxicity in these and other organ systems leading to an integrated Center structure. The Facility Cores will be in Toxicogenomics, Toxicoproteomics and Biomarkers, and will provide investigators with services that would otherwise be unattainable and will propel investigators into the new era of predictive toxicology. The COEP will disseminate the research findings and utilize the expertise of CEET investigators: to enhance K-16 education in environmental health; to conduct community outreach in four environmentally challenged Southeastern Pennsylvania communities, and to enrich the education of health care professionals. The COEP has forged relationships with community partners for outreach. The COEP goal will be to reduce the risk of harmful exposures and improve the public health of vulnerable populations within these communities.