CORE GRANT FOR VISION RESEARCH

描述（由申请人提供）：我们请求继续支持西奈山医学院1977年实施的视觉研究核心中心拨款。核心中心为视觉研究人员提供共享资源，这些资源对于当前研究项目的延续和新项目的有效开发至关重要。我们的中心围绕6个广泛利用的资源和服务模块构建。需要继续为难以用当地资源支助的三个关键模块提供新环境资源资金：机械车间；电子学/计算机和组织学/组织处理。其他三个模块：组织培养；共享设备和细胞成像得到了部门和机构的支持，这是他们对我们的视觉研究科学家的承诺。除了通过提供共同的集中服务来提高研究环境和生产力外，P30奖还刺激和促进了合作研究，并努力吸引其他与健康相关学科的科学家从事视觉研究。我们的小组由11名获得NEI资助的独立研究员，4名副研究员和研究员组成

DESCRIPTION (provided by applicant): We request continuing support for a Vision Research Core Center Grant at the Mount Sinai School of Medicine that was implemented in 1977. The Core Center provides vision researchers with shared resources that are vital for the continuation of current research programs and efficient development of new programs. Our Center is structured around 6 extensively utilized resource and service modules. Continued NEI funding is requested for three critical modules which are difficult to support with local resources: Machine Shop; Electronics/Computers and Histology/Tissue Processing. The other three modules: Tissue Culture; Shared Equipment and Cellular Imaging are supported by the department and the institution, underlying their commitment to our vision research scientists. In addition to enhancing the research environment and productivity by providing common centralized services, the P30 award stimulates and facilitates collaborative studies and strives to attract to vision research, scientists in other health-related disciplines. Our group consists of 11 independent investigators who have NEI grants, 4 associate investigators and fellows conducting research in several scientific disciplines such as biochemistry, pharmacology, physiology, cell biology, and neurology. Areas of active research include glaucoma; cataracts; corneal diseases; comeal repair and immunology; aqueous humor dynamics; fluid and electrolyte transport in cornea, lens and ciliary epithelium; role of membrane receptors in regulation of intraocular pressure; visual control of the oculomotor system; mechanisms of glutamate excitotoxicity in glaucoma and methods of neuroprotection; optical imaging, electrophysiological recordings and computer simulations to study the architecture and dynamics of the visual system; and degenerative diseases of the retina. The group of NEI-funded investigators includes 7 senior faculty with long-standing NEI support, 4 Pis who received NEI R01 funding during the prior grant period, and 3 promising younger investigators who are establishing their competitiveness with pending NEI R01 proposals.