2008 The Biology of Post-Transcriptional Gene Regulation Gordon Research Conferen

描述（由申请人提供）：本提案要求对将于2008年6月29日至7月4日在缅因州沃特维尔的科尔比学院举行的戈登转录后基因调控生物学研究会议提供部分支持。这次会议是每两年举行一次的戈登会议系列的第三次会议。会议的广泛和长期目标是提高我们目前对正常和疾病状态下RNA生物合成的基本机制和调控的理解。重点是涉及mRNA的转录后交易，但这延伸到转录偶联，以及涉及翻译及其控制的因子，包括tRNA和microRNA。本次会议的具体目标是召集约45名代表转录后基因调控关键领域的发言者，共有150名与会者，为期五天。该计划将包括九个上午或晚上的会议，将广泛解决前沿问题：转录和RNA加工之间的耦合; RNA加工信号和因子的基因组学和进化; RNA剪接催化，保真度，调节和参与疾病; RNA周转，包括无义介导的mRNA衰变; RNA运输和定位;非编码RNA;和翻译控制。此外，在四个下午晚些时候举行的小型海报会议将使所有与会者都能对这些专题作出贡献并了解这些专题。在科尔比学院相对孤立的夏季环境中，免费的下午早些时候和晚上很晚的时间将激发来自美国和国外的资深和初级主要研究人员、博士后学员和研究生之间富有成效的非正式讨论。该应用程序的重要性在于，该GRC具有独特的格式，汇集了多组研究人员，尽管他们的兴趣一致，但很少有机会作为一个团体见面。由此产生的讨论和交流将有助于确定推动这一领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。这种应用的健康相关性反映了RNA加工功能障碍在许多遗传疾病、神经和神经肌肉疾病以及癌症中的广泛参与。公共卫生相关性本申请与公共卫生的相关性反映了与许多人类遗传疾病、神经和神经肌肉疾病以及癌症相关的RNA代谢缺陷的广泛参与。此外，阐明基因调控步骤的基本机制是本次会议的重点，对于充分了解人类基因组的组织，功能和进化至关重要。

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference on The Biology of Post-Transcriptional Gene Regulation, to be held at Colby College in Waterville, Maine, from June 29 to July 4, 2008. This meeting is the third one of a Gordon Conference series held every other year. The broad and long-term goal of the conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and microRNAs. The specific aims of this meeting will be to convene approximately 45 speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA-processing signals and factors; RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; and translational control. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early- afternoon and late-evening periods in the relatively isolated summer setting of Colby College will stimulate productive, informal discussions among established and junior principal investigators, postdoctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. PUBLIC HEALTH RELEVANCE The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating the basic mechanisms of the steps of gene regulation that are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.