BIOSTATISTICS/BIOINFORMATICS

描述（由申请人提供）：生物统计学和生物信息学共享设施（BBSF）的主要目标是作为中心研究人员可以从中汲取统计学和生物信息学专业知识以规划、管理和分析其研究的联络点。 生物统计学共享机构的具体目标是：1）协调和管理癌症中心的统计学和生物信息学活动，以确保研究者随时可以获得统计学和生物信息学咨询和支持; 2）提供研究设计方面的统计学专业知识，包括研究提案制定; 3）使用现代统计学和生物信息学方法为癌症中心项目提供数据分析; 4）维护癌症中心临床研究单元的临床试验方案和患者登记数据管理系统，并进一步开发中心临床试验的方案特定数据库; 5）开发和管理 为中心的四个SPORE中的每一个建立综合数据库，作为SPORE研究人员的多学科研究资源; 6）为中心的基因表达和质谱/蛋白质组学共享设施开发和管理基于网络的数据管理系统; 7）为中心的小动物图像共享设施开发和管理图像存储、检索和分析系统; 8）是NCI的癌症生物信息学网格（caBIG）倡议的积极参与者和合作者; 9）维护具有最新数据管理，数据分析和网络通信软件的计算设施;并为癌症中心的数据共享计划提供支持; 10）进行生物统计学和生物信息学的方法研究，这将提高BBSF的技术能力和提供合作研究支持的要求;和11）提供生物统计学和生物信息学的培训机会和教育，研究生，肿瘤住院医师，研究员和癌症中心的研究人员。 BBSF将根据特定的 根据咨询委员会的建议制定使用政策和优先次序准则。

DESCRIPTION (provided by applicant): The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to serve as a focal point from which the Center's investigators may draw statistical and bioinformatic expertise for planning, management and analysis of their studies. The specific aims of the Biostatistics Shared Facility are to: 1) coordinate and manage statistical and bioinformatic activities in the Cancer Center to ensure that investigators have ready access to statistical and bioinformatic consultation and support; 2) provide statistical expertise in study design, including research proposal development; 3) provide data analysis for Cancer Center projects using contemporary statistical and bioinformatic methodologies; 4) maintain the clinical trial protocol and patient registration data management system for the Cancer Center Clinical Studies Unit and further develop protocol specific databases for the Center's clinical trials; 5) develop and manage a comprehensive database for each of the Center's four SPOREs to serve as a multidisciplinary research resource for SPORE investigators; 6) develop and manage web-based data management systems for the Center's Gene Expression and Mass Spectroscopy/Proteomic Shared Facilities; 7) develop and manage image storage, retrieval and analysis system for the Center's Small Animal Image Shared Facility; 8) be an active participant and collaborator of the NCI's Cancer Bioinformatics Grid (caBIG) Initiatives; 9) maintain a computing facility with up-to-date software for data management, data analysis, and network communications; and provide support for the Cancer Center's Data Sharing Plan; 10) perform methodology research in biostatistics and bioinformatics that will enhance the BBSF's technical capabilities and requirements in providing collaborative research support; and 11) provide training opportunities and education in biostatistics and bioinformatics to graduate students, oncology residents, fellows and Cancer Center investigators. The BBSF will be operated under the specific usage policies and priority guidelines established with the advise of its Advisory Committee.