Identification and characterisation of genes required for cardiac morphogenesis

心脏是胚胎形成时第一个开始发挥功能的器官，反映了它在维持生命中的关键作用。心脏发育过程中出现的错误会对个体的生存和健康造成毁灭性的后果。我们已经发现了两种具有心脏缺陷的斑马鱼突变体，并将使用复杂的成像和遗传研究来调查这些缺陷并确定相关基因。这项研究将提高我们对正确和病态心脏形成的理解。

The heart is the first organ to become functional as an embryo forms, reflecting its critical role in sustaining life. Mistakes that occur as the heart develops have devastating consequences for an individualÍs survival and health. We have identified two zebrafish mutants with heart defects and, using sophisticated imaging and genetic studies, will investigate these defects and identify the genes responsible. This research will improve our understanding of correct and diseased heart formation.