Reaearch Methods (Neuroimaging Core)

神经成像核心(NIC)符合《 CIDAR计划公告(PA05-039)；NIC将提供磁共振成像(MRI)和 波谱(MRS)到BITREC。NIC将设在辛辛那提大学(UC)中心 影像研究(CIR)。CIR聘请了许多内科医生、物理学家和神经学家， 作为业务管理员、工程师先生、技术员、软件程序员和IT技术员， 支持其日常运营。李博士是CIR的副主任和高级物理学家，他将 NIC的主管。他将负责整个核心职能和新技术的开发。他还将 监督任何MRI系统升级，确保这些升级不会影响我们实现BITREC的能力 目标。NIC将分为两个部门，反映其主要活动。MRS部门， 由Komoroski博士执导，朱博士担任助理主任，将为技术 BITREC的开发、数据处理和数据分析。核磁共振部门，由埃利亚森博士领导， 将提供功能磁共振数据处理和分析以及开发新的 BITREC要求的神经心理学调查。NIC的教职员工还将与生物统计司合作 运营和临床评估核心，以开发新的方法来整合和分析 临床和影像数据集。NIC教职员工将与项目主要调查人员密切合作，以适当地 应用成像方法来实现所提出的特定目标。除了这一主要责任外， 作为核心设施，国家信息中心还将开发新技术，以支持联合国目前和未来的任务。 BITREC。这些措施将包括开发全自动实时功能磁共振成像引导的磁共振波谱 整合fMRI和MRS数据；31P-MRS多体素技术；以及开发新的认知探针 先进的功能磁共振研究和双相情感障碍的研究。NIC将提供通用映像和 光谱工具，从而允许跨项目进行比较，以及支持每个项目的 具体目标。通过这样做，NIC提供了另一种将活动集成到建议的 BITREC。

The Neuroimaging Core (NIC) fulfills the requirement for a "Research Methods Core" described in the CIDAR Program Announcement (PA05-039); the NIC will provide Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) to the BITREC. The NIC will be based in the University of Cincinnati (UC) Center for Imaging Research (CIR). The CIR employs a number of physicians, MR physicists and neuroscientists, as well as a business administrator, MR engineer, MR technician, software programmer, and IT technician to support its day-to-day operations. Dr. Lee, an Associate Director and the senior physicist of the CIR, will be the Director of the NIC. He will oversee overall core function and novel technology development. He will also supervise any MRI system upgrades to ensure that these do not impact on our ability to achieve BITREC objectives. The NIC will be organized into two divisions reflecting its primary activities. The MRS division, directed by Dr. Komoroski, with Dr. Chu serving as Assistant Director, will provide for MRS technical development, data processing, and data analysis for the BITREC. The MRI division, directed by Dr. Eliassen, will provide for fMRI data processing and analysis as well as for the development of novel neuropsychological probes required by the BITREC. NIC faculty will also work with the Biostatistics Division of the Operations and Clinical Assessment Core in order to develop novel methods to integrate and analyze clinical and imaging datasets. The NIC faculty will work closely with project principal investigators to properly apply imaging methods to accomplish the proposed specific aims. In addition to this primary responsibility, as a core facility, the NIC will also develop novel techniques to support current and future missions of the BITREC. These will include developing fully automated real-time fMRI guided MR spectroscopy for integrating fMRI and MRS data; 31P-MRS multivoxel techniques; and developing novel cognitive probes for advanced fMRI research and the study of bipolar disorder. The NIC will provide common imaging and spectroscopic tools, thereby permitting comparisons across projects, as well as supporting each project's specific goals. By so doing, the NIC provides another means of integrating activities within the proposed BITREC.