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Identification and characterization of novel proteins in endosomal cholesterol transport

Identification and characterization of novel proteins in endosomal cholesterol transport
内体胆固醇转运中新型蛋白质的鉴定和表征
批准号:
nhmrc : 1041301
负责人:
Prof Andrew Brown
金额:
$36.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

项目摘要

项目成果

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中文摘要
翻译
胆固醇的异常亚细胞分布与包括心脏病和阿尔茨海默病在内的许多常见疾病有关。这项提议的总体目标是确定和表征调节细胞内胆固醇运输的新分子。拟议研究的结果将为控制细胞内胆固醇运输和分布的分子机制提供重要见解,并将导致更好的治疗心脏病和痴呆的策略。
英文摘要
Abnormal subcellular distribution of cholesterol is associated with a number of common diseases including heart disease and Alzheimer’s disease. The overall aim of this proposal is to identify and characterize novel molecules that regulate the transport of intracellular cholesterol. Results from the proposed studies will provide important insights into the molecular mechanisms governing intracellular cholesterol transport and distribution, and will lead to better treatment strategies against heart disease and dementia.
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会议论文
Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8)
  • 批准号:
    nhmrc : 1141939
  • 项目类别:
    Project Grants
  • 资助金额:
    $31.53万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Brown
  • 依托单位:
The role of adipose tissue cholesterol in metabolic diseases
  • 批准号:
    nhmrc : 1141938
  • 项目类别:
    Project Grants
  • 资助金额:
    $60.06万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Brown
  • 依托单位:
Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8)
  • 批准号:
    nhmrc : GNT1141939
  • 项目类别:
    Project Grants
  • 资助金额:
    $46.64万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Brown
  • 依托单位:
The role of adipose tissue cholesterol in metabolic diseases
  • 批准号:
    nhmrc : GNT1141938
  • 项目类别:
    Project Grants
  • 资助金额:
    $88.83万
  • 财政年份:
    2018
  • 负责人:
    Prof Andrew Brown
  • 依托单位:
海外基金