Identification and characterization of a novel long intergenic noncoding RNA for the therapy of neuroblastoma
Identification and characterization of a novel long intergenic noncoding RNA for the therapy of neuroblastoma
批准号:
nhmrc : 1023001
负责人:
A/Pr Marcel Dinger
金额:
$40.1万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
神经母细胞瘤是儿童早期最常见的实体瘤。幸存者由于化疗而终身残疾。在这个应用中,我们将确定一个长的基因间非蛋白质编码的RNA的基因扩增在确定神经母细胞瘤癌基因的生物学效应和促进神经母细胞瘤发生和发展中的作用。我们还将确定针对长基因间非蛋白质编码RNA的治疗的抗癌效果。
英文摘要
Neuroblastoma is the commonest solid tumour in early childhood. Survivors suffer from lifelong disabilities due to chemotherapy. In this application, we will define the role of gene amplification of a long intergenic non-protein-coding RNA in determining the biological effects of a neuroblastoma oncogene, and promoting neuroblastoma initiation and progression. We will also define the anti-cancer efficacy of therapies targeting the long intergenic non-protein-coding RNA.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Diagnosis of Inherited Genetic Disorders Using DNA Reference Standards
-
批准号:nhmrc : GNT1139107
-
项目类别:Project Grants
-
资助金额:$69.08万
-
财政年份:2018
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Diagnosis of Inherited Genetic Disorders Using DNA Reference Standards
-
批准号:nhmrc : 1139107
-
项目类别:Project Grants
-
资助金额:$46.71万
-
财政年份:2018
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Synthetic DNA Standards for Clinical Genome Sequencing
-
批准号:nhmrc : GNT1136067
-
项目类别:Development Grants
-
资助金额:$87.0万
-
财政年份:2018
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Synthetic DNA Standards for Clinical Genome Sequencing
-
批准号:nhmrc : 1136067
-
项目类别:Development Grants
-
资助金额:$58.82万
-
财政年份:2018
-
负责人:A/Pr Marcel Dinger
-
依托单位:
The economic impact of providing precision medicine through whole genome sequencing
-
批准号:nhmrc : GNT1151906
-
项目类别:Partnerships
-
资助金额:$114.48万
-
财政年份:2018
-
负责人:A/Pr Marcel Dinger
-
依托单位:
The identification of new epilepsy genes by whole genome sequencing
-
批准号:nhmrc : GNT1125523
-
项目类别:Project Grants
-
资助金额:$106.98万
-
财政年份:2017
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Preconception carrier screening: providing genetically at risk families with a chance to have healthy children
-
批准号:nhmrc : 1146134
-
项目类别:Partnerships
-
资助金额:$57.17万
-
财政年份:2017
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Preconception carrier screening: providing genetically at risk families with a chance to have healthy children
-
批准号:nhmrc : GNT1146134
-
项目类别:Partnerships
-
资助金额:$84.58万
-
财政年份:2017
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Functional characterization and therapeutic targeting of the novel long noncoding RNA MYCN-AS
-
批准号:nhmrc : 1099025
-
项目类别:Project Grants
-
资助金额:$44.36万
-
财政年份:2016
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Functional characterization and therapeutic targeting of the novel long noncoding RNA MYCN-AS
-
批准号:nhmrc : GNT1099025
-
项目类别:Project Grants
-
资助金额:$64.7万
-
财政年份:2016
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Functional characterization of the regulatory architecture of melanoma-associated loci
-
批准号:nhmrc : 1043971
-
项目类别:Project Grants
-
资助金额:$43.05万
-
财政年份:2013
-
负责人:A/Pr Marcel Dinger
-
依托单位:
lncRNAs and mesoderm formation
-
批准号:nhmrc : 1045986
-
项目类别:Project Grants
-
资助金额:$38.34万
-
财政年份:2013
-
负责人:A/Pr Marcel Dinger
-
依托单位:
Noncoding RNAs in neural stem cell differentiation
-
批准号:nhmrc : 631542
-
项目类别:Career Development Fellowships
-
资助金额:$26.3万
-
财政年份:2010
-
负责人:A/Pr Marcel Dinger
-
依托单位:
MicroRNA regulation of sex determination and gonad development.
-
批准号:nhmrc : 631460
-
项目类别:NHMRC Project Grants
-
资助金额:$34.55万
-
财政年份:2010
-
负责人:A/Pr Marcel Dinger
-
依托单位:
海外基金