Quantitative Optical Imaging of Cortical Hemodynamics in Animal Models

描述（由申请人提供）：我们提出开发一种新型的体内光学脑成像系统，用于脑损伤和活动的小动物模型中血流动力学参数的定量映射。该系统是一种双模态调制成像装置，是一种基于空间光调制原理和激光散斑流量计原理的光学成像仪器。血流动力学参数的定量映射将有助于阐明动物模型中疾病和损伤的空间和时间脑血管反应。这个项目的结果将提供一个必要的，统一的硬件和软件平台，这将是第二阶段研究的主力工具，我们将系统地评估脑损伤，疾病和功能范例的模型。未来的商业产品将有利于基础和应用研究的科学家，他们正在研究和开发中风，创伤，癫痫，偏头痛，神经退行性疾病的诊断和治疗策略，以及药物的影响，以及正在研究功能活动和可塑性的神经生物学家。

DESCRIPTION (provided by applicant): We propose to develop a novel in-vivo optical brain imaging system for quantitative mapping of hemodynamic parameters in small animal models of brain injury and activity. This system will be a dual-modality modulated imaging device, an optical imaging instrument based on principles of spatial light modulation and laser speckle flowmetry. Quantitative mapping of hemodynamic parameters will then help elucidate spatial and temporal cerebrovascular responses to diseases and injuries in animal models. The results of this proposed project will provide an essential, unified hardware and software platform that will be the workhorse instrument for Phase II studies in which we will systematically assess models of brain injury, disease, and functional paradigms. The future commercial product will benefit scientists in basic and applied research who are studying and developing diagnostic and therapeutic strategies for stroke, trauma, epilepsy, migraine, neurodegenerative diseases, and the impact of pharmacologic agents, as well as neurobiologists who are investigating functional activity and plasticity.